Case Center for Synchrotron Biosciences

We are a Research Resource Center funded by the National Institute of Biomedical Imaging and Bioengineering serving an international community of biomedical scientists.

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Many of the advances in structural molecular biology and related biosciences are the result of the rapidly occurring developments at synchrotrons. These include X-ray crystallography for protein structure determination, X-ray spectroscopy for examination of metalloprotein structure, and synchrotron footprinting technologies for examining macromolecular structure and dynamics. The Case School of Medicine of Case Western Reserve University established the Case Center for Proteomics and Bioinformatics for expanding the state-of-the art in proteomics research. This center provides administrative oversight for the Case Center for Synchrotron Biosciences (CSB) which is funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) as a Biotechnology Research Resource to serve an international community of biomedical scientists. The CSB is catalyzing further development and application of synchrotron radiation tools through a number of multidisciplinary collaborations and partnerships among an international community of scientists. The research facility located at the Photon Sciences at the Brookhaven National Laboratory (BNL) in New York. Photon Sciences, as a Department of Energy funded facility, has as a mission to provide academic institutions access to synchrotron light through various collaboration and consortium arrangements.

What's New at the CSB

Transition to NSLS-II
The CSB's current home at the NSLS will shut down September 30, 2014. While all CSB programs are going full blast at NSLS until the last photon fades, plans are in full swing for moving across the street to the new, state-of-the-art facility at NSLS-II in a phased multi-year transition. For X-ray synchrotron footprinting, the CSB is constructing a dedicated beamline (XFP), scheduled to come online in late 2015. In the interim we will provide additional X-ray synchrotron footprinting resources on the West Coast at the ALS. The X-ray absorption spectroscopy program will continue via partnerships with NSLS-II X-ray spectroscopy beamlines ISS and BMM, both of which should be operational by mid-to-late 2016. A partnership with SSRL to provide additional capacity for XAS during 2015-2016 is being developed by the Directors for Science at both SSRL and NSLS-II. We are also planning to continue our productive macromolecular crystallography partnership by working with NSLS-II beamlines FMX and AMX. Finally, we are seeking to expand the Center's scientific repertoire by partnering with an NSLS-II beamline for small angle X-ray solution scattering (LIX). We are establishing an Integrated Biophysics Program to promote multi-technique approach including footprinting, crystallography, small angle solution scattering and XAS for structure determination. Collectively, these resources will provide a wide array of biophysical characterization tools at NSLS-II for CSB facility users.