Many of the advances in structural molecular biology and
related biosciences are the result of the rapidly occurring developments at
synchrotrons. These include X-ray crystallography for protein structure
determination, X-ray spectroscopy for examination of metalloprotein
structure, and synchrotron footprinting technologies for examining
macromolecular structure and dynamics. The Case School of Medicine of Case
Western Reserve University established the Case Center for
Proteomics and Bioinformatics for expanding the state-of-the art in
proteomics research. This center provides administrative oversight for the
Case Center for Synchrotron Biosciences (CSB) which is funded by the
National Institute of Biomedical Imaging and Bioengineering (NIBIB) as a
Biotechnology Research Resource to serve an international community of
biomedical scientists. The CSB is catalyzing further development and
application of synchrotron radiation tools through a number of
multidisciplinary collaborations and partnerships among an international
community of scientists. The research facility located at the Photon Sciences at the Brookhaven National Laboratory (BNL)
in New York. Photon Sciences, as a Department of Energy funded facility, has as a
mission to provide academic institutions access to synchrotron light
through various collaboration and consortium arrangements.
What's New at the CSB
Transition to NSLS-II
The CSB's current home at the NSLS will shut down September 30, 2014.
While all CSB programs are going full blast at NSLS until the last photon
fades, plans are in full swing for moving across the street to the new,
state-of-the-art facility at NSLS-II in a phased multi-year transition.
For X-ray synchrotron footprinting, the CSB is constructing a dedicated
beamline (XFP), scheduled to come online in late 2015. In the interim we
will provide additional X-ray synchrotron footprinting resources on the
West Coast at the ALS. The X-ray absorption spectroscopy program will
continue via partnerships with NSLS-II X-ray spectroscopy beamlines ISS and
BMM, both of which should be operational by mid-to-late 2016. A
partnership with SSRL to provide additional capacity for XAS during
2015-2016 is being developed by the Directors for Science at both SSRL and
NSLS-II. We are also planning to continue our productive macromolecular
crystallography partnership by working with NSLS-II beamlines FMX and AMX.
Finally, we are seeking to expand the Center's scientific repertoire by
partnering with an NSLS-II beamline for small angle X-ray solution
We are establishing an Integrated Biophysics Program to promote multi-technique approach including footprinting, crystallography, small angle solution scattering and XAS for structure determination.
Collectively, these resources will provide a wide array
of biophysical characterization tools at NSLS-II for CSB facility users.