Publications 2008-2013

X28C - Hydroxyl Radical Mediated Footprinting (Core A)

In Press
  • Bohon J., D.Mello R., Ralston C., Gupta S., Chance MR. Synchrotron Footprinting on Tour. J. Synch. Rad.
  • Soper, S. F. C., Dator, R. P., Limbach, P. A. and Woodson, S. A. In vivo X-ray footprinting of pre-30S ribosomes reveals chaperone-dependent remodeling of late assembly intermediates. Mol. Cell.
2013
  • Deperalta G, Alvarez M, Bechtel C, Dong K, McDonald R, Ling V. Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting. mAbs. 2013;5(1):86-101. doi: 10.4161/mabs.22964. PubMed PMID: 23247543; PubMed Central PMCID: PMC3564890.
  • Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, et al. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Molecular & cellular proteomics : MCP. 2013;12(5):1259-71. doi: 10.1074/mcp.M112.025536. PubMed PMID: 23378516; PubMed Central PMCID: PMC3650337.
2012
  • Gupta S, D'Mello R, Chance MR. Structure and dynamics of protein waters revealed by radiolysis and mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(37):14882-7. doi: 10.1073/pnas.1209060109. PubMed PMID: 22927377; PubMed Central PMCID: PMC3443160.
  • Kaur P, Chance, M.R. The Utility of Mass Spectrometry Based Structural Proteomics in Biopharmaceutical Biologics Development. Integrative Proteomics2012.
  • Muller EM, Smedley J, Bohon J, Yang X, Gaowei M, Skinner J, et al. Transmission-mode diamond white-beam position monitor at NSLS. Journal of synchrotron radiation. 2012;19(Pt 3):381-7. doi: 10.1107/S0909049512005043. PubMed PMID: 22514173; PubMed Central PMCID: PMC3329958.
  • Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, et al. Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure. 2012;20(5):826-40. doi: 10.1016/j.str.2012.03.017. PubMed PMID: 22579250; PubMed Central PMCID: PMC3351692.
  • Pacholarz KJ, Garlish RA, Taylor RJ, Barran PE. Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery. Chemical Society reviews. 2012;41(11):4335-55. doi: 10.1039/c2cs35035a. PubMed PMID: 22532017.
2011
  • Chaudhuri BN, Gupta S, Urban VS, Chance MR, D'Mello R, Smith L, et al. A combined global and local approach to elucidate spatial organization of the Mycobacterial ParB-parS partition assembly. Biochemistry. 2011;50(11):1799-807. doi: 10.1021/bi1016759. PubMed PMID: 21142182; PubMed Central PMCID: PMC3081668.
  • Keister JW, Smedley J, Muller EM, Bohon J, Heroux A. Diamond X-ray Photodiode for White and Monochromatic SR beams. Nuclear instruments & methods in physics research Section A, Accelerators, spectrometers, detectors and associated equipment. 2011;649(1):91-3. doi: 10.1016/j.nima.2010.11.135. PubMed PMID: 21822344; PubMed Central PMCID: PMC3150571.
  • Kiselar JG, Datt M, Chance MR, Weiss MA. Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling. The Journal of biological chemistry. 2011;286(51):43710-6. doi: 10.1074/jbc.M111.297853. PubMed PMID: 22033917; PubMed Central PMCID: PMC3243561.
  • Oztug Durer ZA, Kamal JK, Benchaar S, Chance MR, Reisler E. Myosin binding surface on actin probed by hydroxyl radical footprinting and site-directed labels. Journal of molecular biology. 2011;414(2):204-16. doi: 10.1016/j.jmb.2011.09.035. PubMed PMID: 21986200; PubMed Central PMCID: PMC3221818.
  • Wang L, Chance MR. Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting. Analytical chemistry. 2011;83(19):7234-41. doi: 10.1021/ac200567u. PubMed PMID: 21770468; PubMed Central PMCID: PMC3184339.
  • Woodson SA. RNA folding pathways and the self-assembly of ribosomes. Accounts of chemical research. 2011;44(12):1312-9. doi: 10.1021/ar2000474. PubMed PMID: 21714483.
2010
  • Bohon J, Smedley, J., Muller, E.M., Keister, J.W. Development of Diamond-Based X-ray Detection for High Flux Beamline Diagnostics, in Diamond Electronics and Bioelectronics - Fundamentals to Applications III. MRS '09 2010.
  • Bohon J, Muller E, Smedley J. Development of diamond-based X-ray detection for high-flux beamline diagnostics. Journal of synchrotron radiation. 2010;17(6):711-8. doi: 10.1107/S0909049510031420. PubMed PMID: 20975215; PubMed Central PMCID: PMC3089012.
  • Chang X, Wu Q, Ben-Zvi I, Burrill A, Kewisch J, Rao T, et al. Electron beam emission from a diamond-amplifier cathode. Physical review letters. 2010;105(16):164801. PubMed PMID: 21230979.
  • Gupta S, Bavro VN, D'Mello R, Tucker SJ, Venien-Bryan C, Chance MR. Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry. Structure. 2010;18(7):839-46. doi: 10.1016/j.str.2010.04.012. PubMed PMID: 20637420; PubMed Central PMCID: PMC3124773.
  • Keister JW, Smedley, J., Muller, E.M., Bohon, J. Responsivity of Diamond X-ray Photodiodes Calibrated at NSLS. Upton, N.Y. Oak Ridge, Tenn.: Brookhaven National Laboratory ; distributed by the Office of Scientific and Technical Information U.S. Dept. of Energy; 2009. Available from: http://www.osti.gov/servlets/purl/970615-DnNNcm/.
  • Kiselar JG, Chance MR. Future directions of structural mass spectrometry using hydroxyl radical footprinting. Journal of mass spectrometry : JMS. 2010;45(12):1373-82. doi: 10.1002/jms.1808. PubMed PMID: 20812376; PubMed Central PMCID: PMC3012749.
  • Liu S, Tian Y, Greenaway FT, Sun MZ. A C-terminal hydrophobic, solvent-protected core and a flexible N-terminus are potentially required for human papillomavirus 18 E7 protein functionality. Biochimie. 2010;92(7):901-8. doi: 10.1016/j.biochi.2010.02.028. PubMed PMID: 20211680.
  • Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, et al. Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010;18(1):116-26. doi: 10.1016/j.str.2009.11.008. PubMed PMID: 20152158; PubMed Central PMCID: PMC2822722.
  • Orban T, Gupta S, Palczewski K, Chance MR. Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010;49(5):827-34. doi: 10.1021/bi901889t. PubMed PMID: 20047303; PubMed Central PMCID: PMC2819031.
  • Shi W, Bohon J, Han DP, Habte H, Qin Y, Cho MW, et al. Structural characterization of HIV gp41 with the membrane-proximal external region. The Journal of biological chemistry. 2010;285(31):24290-8. doi: 10.1074/jbc.M110.111351. PubMed PMID: 20525690; PubMed Central PMCID: PMC2911339.
  • Smedley J, Ben-Zvi, I., Chang, X., Johnson, P., Rameau, J., Rao, T., Wu, Q., Muller, E., Bohon, J. . Electron Transport and Emission in Diamond. IPAC'10; Kyoto, Japan 2010.
  • Smedley J, Keister, J.W., Muller, E.M., Jordan-Sweet, J., Bohon, J., Distel, J., Dong, B. Photodiodes for X-ray Applications, in Diamond Electronics and Bioelectronics - Fundamentals to Applications III. MRS '09 2010.
  • Wang L, Qin Y, Ilchenko S, Bohon J, Shi W, Cho MW, et al. Structural analysis of a highly glycosylated and unliganded gp120-based antigen using mass spectrometry. Biochemistry. 2010;49(42):9032-45. doi: 10.1021/bi1011332. PubMed PMID: 20825246; PubMed Central PMCID: PMC2957511.
2009
  • Adilakshmi T, Soper SF, Woodson SA. Structural analysis of RNA in living cells by in vivo synchrotron X-ray footprinting. Methods in enzymology. 2009;468:239-58. doi: 10.1016/S0076-6879(09)68012-5. PubMed PMID: 20946773; PubMed Central PMCID: PMC3144761.
  • Angel TE, Chance MR, Palczewski K. Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(21):8555-60. doi: 10.1073/pnas.0903545106. PubMed PMID: 19433801; PubMed Central PMCID: PMC2688986.
  • Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR. Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(34):14367-72. doi: 10.1073/pnas.0901074106. PubMed PMID: 19706523; PubMed Central PMCID: PMC2732891.
  • Kaur P, Kiselar JG, Chance MR. Integrated algorithms for high-throughput examination of covalently labeled biomolecules by structural mass spectrometry. Analytical chemistry. 2009;81(19):8141-9. doi: 10.1021/ac9013644. PubMed PMID: 19788317; PubMed Central PMCID: PMC2764328
2008
  • Adilakshmi T, Bellur DL, Woodson SA. Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly. Nature. 2008;455(7217):1268-72. doi: 10.1038/nature07298. PubMed PMID: 18784650; PubMed Central PMCID: PMC2720798.
  • Benchaar S, Reisler, E. Complex Formation in the Actin Cytoskeleton: Cross-linking Tools to Define Actin Protein Structure and Interactions. In: Chance MR, editor. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics: Wiley; 2008. p. 169-87.
  • Bohon J, Jennings LD, Phillips CM, Licht S, Chance MR. Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loop. Structure. 2008;16(8):1157-65. doi: 10.1016/j.str.2008.04.016. PubMed PMID: 18682217; PubMed Central PMCID: PMC2929679.
  • Jennings LD, Bohon J, Chance MR, Licht S. The ClpP N-terminus coordinates substrate access with protease active site reactivity. Biochemistry. 2008;47(42):11031-40. doi: 10.1021/bi8010169. PubMed PMID: 18816064; PubMed Central PMCID: PMC2920337.
  • Kamal A. Computational Approaches to Examining Protein-Protein Interactions: Combining Experimental and Computational Data in the Era of Structural Genomics. In: Chance MR, editor. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics: Wiley; 2008. p. 189-215.
  • Swiatkowski SM, Chance, M. R. Overview of Mass Spectrometry Technologies for Examining Protein Structure: Current and Future Directions. In: Chance MR, editor. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics: Wiley; 2008.
  • Takamoto K, Kiselar, J. Covalent Labeling Methods for Examining Protein Structure and Protein Interactions, Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics. In: Chance MR, editor. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics: Wiley; 2008.
  • Zheng X, Wintrode, P. Complementary Methods for Structure Determination: Hydroxyl-Radical Mediated Footprinting and Deuterium Exchange Mass Spectrometry as Applied to Serpin Structure. In: Chance MR, editor. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics: Wiley; 2008.
Theses
  • Clatterbuck Soper SF. Late steps in 30S ribosome assembly in vivo: Johns Hopkins University; 2013.
  • Jennings L. Translocation and Proteolysis by the Energy-Dependent Protease ClpAP: Coordination of Conformational Changes and Active Site Chemistry [Ph.D.] 2008.

X3B - X-ray Absorption Spectroscopy (Core B)

2013
  • Bourassa MW, Leskovjan, A.C., Tappero, R.V., Farquhar, E.R., Colton, C.A., Van Nostrand, W.E., Miller, L. M. Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer.s disease that exhibit neurodegeneration. Biomedical Spectroscopy and Imaging. 2013(2).
  • Dutta A, Flores M, Roy S, Schmitt JC, Hamilton GA, Hartnett HE, et al. Sequential oxidations of thiolates and the cobalt metallocenter in a synthetic metallopeptide: implications for the biosynthesis of nitrile hydratase. Inorganic chemistry. 2013;52(9):5236-45. doi: 10.1021/ic400171z. PubMed PMID: 23587023.
  • Fu Y, Tsui HC, Bruce KE, Sham LT, Higgins KA, Lisher JP, et al. A new structural paradigm in copper resistance in Streptococcus pneumoniae. Nature chemical biology. 2013;9(3):177-83. doi: 10.1038/nchembio.1168. PubMed PMID: 23354287; PubMed Central PMCID: PMC3578076.
  • Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, et al. Manganese transport via the transferrin mechanism. Neurotoxicology. 2013;34:118-27. doi: 10.1016/j.neuro.2012.10.018. PubMed PMID: 23146871; PubMed Central PMCID: PMC3576891.
  • Higgins KA, Hu HQ, Chivers PT, Maroney MJ. Effects of select histidine to cysteine mutations on transcriptional regulation by Escherichia coli RcnR. Biochemistry. 2013;52(1):84-97. doi: 10.1021/bi300886q. PubMed PMID: 23215580; PubMed Central PMCID: PMC3610428.
  • Kundu S, Pfaff FF, Miceli E, Zaharieva I, Herwig C, Yao S, et al. A high-valent heterobimetallic [Cu(III)(mu-O)2Ni(III)]2+ core with nucleophilic oxo groups. Angewandte Chemie. 2013;52(21):5622-6. doi: 10.1002/anie.201300861. PubMed PMID: 23589478.
  • Leto DF, Ingram R, Day VW, Jackson TA. Spectroscopic properties and reactivity of a mononuclear oxomanganese(IV) complex. Chemical communications. 2013;49(47):5378-80. doi: 10.1039/c3cc00244f. PubMed PMID: 23657204.
  • Li F, Van Heuvelen KM, Meier KK, Munck E, Que L, Jr. Sc(3+)-Triggered Oxoiron(IV) Formation from O2 and its Non-Heme Iron(II) Precursor via a Sc(3+)-Peroxo-Fe(3+) Intermediate. Journal of the American Chemical Society. 2013;135(28):10198-201. doi: 10.1021/ja402645y. PubMed PMID: 23802702.
  • Mousavi A, Marts AR, Tierney DL, Cabaniss SE. Geometry of Zn(II) complexes with dissolved organic matter: X-ray studies at variable pH. Toxicol Environ Chem. 2013;95(1):38-44. doi: Doi 10.1080/02772248.2012.734620. PubMed PMID: WOS:000315156400004.
  • Peck KL, Clewett HS, Schmitt JC, Shearer J. Copper ligation to soluble oligomers of the English mutant of the amyloid-beta peptide yields a linear Cu(I) site that is resistant to O2 oxidation. Chemical communications. 2013;49(42):4797-9. doi: 10.1039/c3cc40326b. PubMed PMID: 23608950; PubMed Central PMCID: PMC3697824.
  • Shearer J. Use of a metallopeptide-based mimic provides evidence for a proton-coupled electron-transfer mechanism for superoxide reduction by nickel-containing superoxide dismutase. Angewandte Chemie. 2013;52(9):2569-72. doi: 10.1002/anie.201209746. PubMed PMID: 23341243.
  • Udi Y, Fragai M, Grossman M, Mitternacht S, Arad-Yellin R, Calderone V, et al. Unraveling hidden regulatory sites in structurally homologous metalloproteases. Journal of molecular biology. 2013;425(13):2330-46. doi: 10.1016/j.jmb.2013.04.009. PubMed PMID: 23583775.
  • Wang D, Ray K, Collins MJ, Farquhar ER, Frisch JR, Gomez L, et al. Nonheme Oxoiron(IV) Complexes of Pentadentate N5 Ligands: Spectroscopy, Electrochemistry, and Oxidative Reactivity. Chemical science. 2013;4(1):282-91. doi: 10.1039/C2SC21318D. PubMed PMID: 23227304; PubMed Central PMCID: PMC3515645.
2012
  • Breece RM, Llarrull LI, Tioni MF, Vila AJ, Tierney DL. X-ray absorption spectroscopy of metal site speciation in the metallo-beta-lactamase BcII from Bacillus cereus. Journal of inorganic biochemistry. 2012;111:182-6. doi: 10.1016/j.jinorgbio.2011.12.013. PubMed PMID: 22381913; PubMed Central PMCID: PMC3571675.
  • Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. The Journal of biological chemistry. 2012;287(16):13356-70. doi: 10.1074/jbc.M112.347518. PubMed PMID: 22356908; PubMed Central PMCID: PMC3339940.
  • Dai Z, Farquhar ER, Arora DP, Boon EM. Is histidine dissociation a critical component of the NO/H-NOX signaling mechanism? Insights from X-ray absorption spectroscopy. Dalton transactions. 2012;41(26):7984-93. doi: 10.1039/c2dt30147d. PubMed PMID: 22430114; PubMed Central PMCID: PMC3671924.
  • Hensley MP, Gunasekera TS, Easton JA, Sigdel TK, Sugarbaker SA, Klingbeil L, et al. Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli. Journal of inorganic biochemistry. 2012;111:164-72. doi: 10.1016/j.jinorgbio.2011.11.022. PubMed PMID: 22196016; PubMed Central PMCID: PMC3325339.
  • Higgins KA, Carr CE, Maroney MJ. Specific metal recognition in nickel trafficking. Biochemistry. 2012;51(40):7816-32. doi: 10.1021/bi300981m. PubMed PMID: 22970729; PubMed Central PMCID: PMC3502001.
  • Higgins KA, Chivers PT, Maroney MJ. Role of the N-terminus in determining metal-specific responses in the E. coli Ni- and Co-responsive metalloregulator, RcnR. Journal of the American Chemical Society. 2012;134(16):7081-93. doi: 10.1021/ja300834b. PubMed PMID: 22471551; PubMed Central PMCID: PMC3375346.
  • Hong J, Wang, X., Wang, Q., Omenya, F. , Chernova, N., Whittingham, M., Graetz, J. Structure and Electrochemistry of Vanadium-Modified LiFePO4. J Phys Chem C. 2012.
  • Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(41):E2747-56. doi: 10.1073/pnas.1212025109. PubMed PMID: 23012475; PubMed Central PMCID: PMC3478654.
  • Kramm UI, Herranz J, Larouche N, Arruda TM, Lefevre M, Jaouen F, et al. Structure of the catalytic sites in Fe/N/C-catalysts for O2-reduction in PEM fuel cells. Physical chemistry chemical physics : PCCP. 2012;14(33):11673-88. doi: 10.1039/c2cp41957b. PubMed PMID: 22824866; PubMed Central PMCID: PMC3429934.
  • Kundu S, Miceli E, Farquhar E, Pfaff FF, Kuhlmann U, Hildebrandt P, et al. Lewis acid trapping of an elusive copper-tosylnitrene intermediate using scandium triflate. Journal of the American Chemical Society. 2012;134(36):14710-3. doi: 10.1021/ja306674h. PubMed PMID: 22928636.
  • Lacina D, Yang, L., Chopra, I., Muckerman, J., Chabal, Y., Graetz, J. Investigation of LiAlH4.THF Formation by Direct Hydrogenation of Catalyzed Al and LiH. Phys Chem Chem Phys. 2012. doi: 10.1039/c2cp40493a.
  • Martin-Diaconescu V, Maroney, M.J. Nickel Bioinorganic Systems. Comprehensive Inorganic Chemistry 2012.
  • McDonald AR, Guo Y, Vu VV, Bominaar EL, Munck E, Que L, Jr. A Mononuclear Carboxylate-Rich Oxoiron(IV) Complex: a Structural and Functional Mimic of TauD Intermediate 'J'. Chemical science. 2012;3:1680-93. doi: 10.1039/C2SC01044E. PubMed PMID: 23267430; PubMed Central PMCID: PMC3528080.
  • McDonald AR, Van Heuvelen KM, Guo Y, Li F, Bominaar EL, Munck E, et al. Characterization of a thiolato iron(III) Peroxy dianion complex. Angewandte Chemie. 2012;51(36):9132-6. doi: 10.1002/anie.201203602. PubMed PMID: 22888066; PubMed Central PMCID: PMC3448492.
  • Ryan KC, Maroney, M.J. Nickel Superoxide Dismutase. Encyclopedia of Metalloproteins 2012.
  • Song H, Wilson DL, Farquhar ER, Lewis EA, Emerson JP. Revisiting zinc coordination in human carbonic anhydrase II. Inorganic chemistry. 2012;51(20):11098-105. doi: 10.1021/ic301645j. PubMed PMID: 23030313.
  • Tyson TA, Yu T, Han SJ, Croft M, Gu GD, Dimitrov IK, et al. Local structure of the superconductor K0.8Fe1.6+xSe2: Evidence of large structural disorder. Phys Rev B. 2012;85(2). doi: Artn 024504Doi 10.1103/Physrevb.85.024504. PubMed PMID: WOS:000298862700006.
  • Yang H, Aitha M, Hetrick AM, Richmond TK, Tierney DL, Crowder MW. Mechanistic and Spectroscopic Studies of Metallo-beta-lactamase NDM-1. Biochemistry. 2012;51(18):3839-47. doi: Doi 10.1021/Bi300056y. PubMed PMID: WOS:000303628200015.
  • Zielazinski EL, Cutsail GE, 3rd, Hoffman BM, Stemmler TL, Rosenzweig AC. Characterization of a cobalt-specific P(1B)-ATPase. Biochemistry. 2012;51(40):7891-900. doi: 10.1021/bi3006708. PubMed PMID: 22971227; PubMed Central PMCID: PMC3478102.
2011
  • Akabayov B, Kulczyk AW, Akabayov SR, Theile C, McLaughlin LW, Beauchamp B, et al. Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7. The Journal of biological chemistry. 2011;286(33):29146-57. doi: 10.1074/jbc.M111.250944. PubMed PMID: 21697085; PubMed Central PMCID: PMC3190722.
  • Akabayov B, Richardson CC. Binding of Mn-deoxyribonucleoside triphosphates to the active site of the DNA polymerase of bacteriophage T7. Powder Diffr. 2011;26(2):159-62. doi: Doi 10.1154/1.3583156. PubMed PMID: WOS:000292367600012.
  • Dai Z, Boon EM. Probing the local electronic and geometric properties of the heme iron center in a H-NOX domain. Journal of inorganic biochemistry. 2011;105(6):784-92. doi: 10.1016/j.jinorgbio.2011.03.002. PubMed PMID: 21497576; PubMed Central PMCID: PMC3137124.
  • England J, Guo Y, Van Heuvelen KM, Cranswick MA, Rohde GT, Bominaar EL, et al. A more reactive trigonal-bipyramidal high-spin oxoiron(IV) complex with a cis-labile site. Journal of the American Chemical Society. 2011;133(31):11880-3. doi: 10.1021/ja2040909. PubMed PMID: 21739994; PubMed Central PMCID: PMC3150404.
  • Farmand M, Jiang DL, Wang BH, Ghosh S, Ramaker DE, Licht S. Super-iron nanoparticles with facile cathodic charge transfer. Electrochem Commun. 2011;13(9):909-12. doi: DOI 10.1016/j.elecom.2011.03.039. PubMed PMID: WOS:000294940600004.
  • Griffin DH, Richmond TK, Sanchez C, Moller AJ, Breece RM, Tierney DL, et al. Structural and Kinetic Studies on Metallo-beta-lactamase IMP-1. Biochemistry. 2011;50(42):9125-34. doi: Doi 10.1021/Bi200839h. PubMed PMID: WOS:000295898600014.
  • Grossman M, Born B, Heyden M, Tworowski D, Fields GB, Sagi I, et al. Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site. Nature structural & molecular biology. 2011;18(10):1102-8. doi: 10.1038/nsmb.2120. PubMed PMID: 21926991; PubMed Central PMCID: PMC3308126.
  • Hensley MP, Tierney DL, Crowder MW. Zn(II) binding to Escherichia coli 70S ribosomes. Biochemistry. 2011;50(46):9937-9. doi: 10.1021/bi200619w. PubMed PMID: 22026583; PubMed Central PMCID: PMC3220600.
  • Herranz J, Jaouen, F., Lefevre, M., Kramm, U.I., Proietti, E., Dodelet, J.-P., Bogdanoff, P., Fiechter, S., Abs-Wurmbach, I., Bertand, P., Arruda, T.M., Mukerjee, S., . Unveiling N-Protonation and Anion-Binding Effects on Fe/N/C Catalysts for O2 Reduction in Proton-Exchange-Membrane Fuel Cells. J Phys Chem C. 2011. doi: 10.1021/jp2042526.
  • Lacina D, Reilly J, Celebi Y, Wegrzyn J, Johnson J, Graetz J. Regeneration of Aluminum Hydride Using Trimethylamine. J Phys Chem C. 2011;115(9):3789-93. doi: Doi 10.1021/Jp1106263. PubMed PMID: WOS:000287833200037.
  • Li Z, Liu Z, Cho DW, Zou J, Gong M, Breece RM, et al. Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase. Journal of inorganic biochemistry. 2011;105(4):509-17. doi: 10.1016/j.jinorgbio.2010.12.012. PubMed PMID: 21333622; PubMed Central PMCID: PMC3071891.
  • Shakya R, Allard MM, Johann M, Heeg MJ, Rentschler E, Shearer JM, et al. Modeling the Geometric, Electronic, and Redox Properties of Iron(III)-Containing Amphiphiles with Asymmetric [NN ' O] Headgroups. Inorganic chemistry. 2011;50(17):8356-66. doi: Doi 10.1021/Ic2009368. PubMed PMID: WOS:000294242700058.
  • Shearer J, Rosenkoetter KE, Callan PE, Pham C. One octarepeate expansion to the human prion protein alters both the Zn2+ and Cu2+ coordination environments within the octarepeate domain. Inorganic chemistry. 2011;50(4):1173-5. doi: 10.1021/ic102294u. PubMed PMID: 21250682; PubMed Central PMCID: PMC3066180.
  • Tran NG, Kalyvas H, Skodje KM, Hayashi T, Moenne-Loccoz P, Callan PE, et al. Phenol nitration induced by an {Fe(NO)2}(10) dinitrosyl iron complex. Journal of the American Chemical Society. 2011;133(5):1184-7. doi: 10.1021/ja108313u. PubMed PMID: 21244001; PubMed Central PMCID: PMC3057220.
  • Wang HC, Riahi M, Pothen J, Bayse CA, Riggs-Gelasco P, Brumaghim JL. Interactions of Cu(I) with selenium-containing amino acids determined by NMR, XAS, and DFT studies. Inorganic chemistry. 2011;50(21):10893-900. doi: 10.1021/ic201440j. PubMed PMID: 21999616; PubMed Central PMCID: PMC3286356.
2010
  • Cook JD, Kondapalli KC, Rawat S, Childs WC, Murugesan Y, Dancis A, et al. Molecular details of the yeast frataxin-Isu1 interaction during mitochondrial Fe-S cluster assembly. Biochemistry. 2010;49(40):8756-65. doi: 10.1021/bi1008613. PubMed PMID: 20815377; PubMed Central PMCID: PMC3005940.
  • Dutta I, Carpenter MK, Balogh MP, Ziegelbauer JM, Moylan TE, Atwan MH, et al. Electrochemical and Structural Study of a Chemically Dealloyed PtCu Oxygen Reduction Catalyst. J Phys Chem C. 2010;114(39):16309-20. doi: Doi 10.1021/Jp106042z. PubMed PMID: WOS:000282209800033.
  • England J, Guo Y, Farquhar ER, Young VG, Jr., Munck E, Que L, Jr. The crystal structure of a high-spin oxoiron(IV) complex and characterization of its self-decay pathway. Journal of the American Chemical Society. 2010;132(25):8635-44. doi: 10.1021/ja100366c. PubMed PMID: 20568768; PubMed Central PMCID: PMC2903234.
  • Herbst RW, Perovic I, Martin-Diaconescu V, O'Brien K, Chivers PT, Pochapsky SS, et al. Communication between the zinc and nickel sites in dimeric HypA: metal recognition and pH sensing. Journal of the American Chemical Society. 2010;132(30):10338-51. doi: 10.1021/ja1005724. PubMed PMID: 20662514; PubMed Central PMCID: PMC2934764.
  • Lesh FD, Shanmugam R, Allard MM, Lanznaster M, Heeg MJ, Rodgers MT, et al. A modular approach to redox-active multimetallic hydrophobes of discoid topology. Inorganic chemistry. 2010;49(16):7226-8. doi: 10.1021/ic1009626. PubMed PMID: 20690730; PubMed Central PMCID: PMC3124133.
  • Mathrubootham V, Thomas J, Staples R, McCraken J, Shearer J, Hegg EL. Bisamidate and mixed amine/amidate NiN2S2 complexes as models for nickel-containing acetyl coenzyme A synthase and superoxide dismutase: an experimental and computational study. Inorganic chemistry. 2010;49(12):5393-406. doi: 10.1021/ic9023053. PubMed PMID: 20507077; PubMed Central PMCID: PMC2898278.
  • McDonald AR, Bukowski MR, Farquhar ER, Jackson TA, Koehntop KD, Seo MS, et al. Sulfur versus Iron Oxidation in an Iron-Thiolate Model Complex. Journal of the American Chemical Society. 2010;132(48):17118-29. doi: 10.1021/ja1045428. PubMed PMID: 21070030; PubMed Central PMCID: PMC3049993.
  • Rouffet M, de Oliveira CA, Udi Y, Agrawal A, Sagi I, McCammon JA, et al. From sensors to silencers: quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases. Journal of the American Chemical Society. 2010;132(24):8232-3. doi: 10.1021/ja101088j. PubMed PMID: 20507095; PubMed Central PMCID: PMC2886603.
  • Ryan KC, Johnson OE, Cabelli DE, Brunold TC, Maroney MJ. Nickel superoxide dismutase: structural and functional roles of Cys2 and Cys6. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2010;15(5):795-807. doi: 10.1007/s00775-010-0645-y. PubMed PMID: 20333421; PubMed Central PMCID: PMC3010328.
  • Shearer J, Callan PE, Amie J. Use of metallopeptide based mimics demonstrates that the metalloprotein nitrile hydratase requires two oxidized cysteinates for catalytic activity. Inorganic chemistry. 2010;49(19):9064-77. doi: 10.1021/ic101765h. PubMed PMID: 20831172; PubMed Central PMCID: PMC3570060.
  • Shearer J, Callan PE, Tran T, Szalai VA. Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-beta oligomers compared to amyloid-beta monomers. Chemical communications. 2010;46(48):9137-9. doi: 10.1039/c0cc02446e. PubMed PMID: 21060917; PubMed Central PMCID: PMC3082590.
  • Stone EM, Glazer ES, Chantranupong L, Cherukuri P, Breece RM, Tierney DL, et al. Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines. ACS chemical biology. 2010;5(3):333-42. doi: 10.1021/cb900267j. PubMed PMID: 20050660; PubMed Central PMCID: PMC2842482.
  • Zaytsev DV, Xie F, Mukherjee M, Bludin A, Demeler B, Breece RM, et al. Nanometer to millimeter scale peptide-porphyrin materials. Biomacromolecules. 2010;11(10):2602-9. doi: 10.1021/bm100540t. PubMed PMID: 20804210; PubMed Central PMCID: PMC2952671.
2009
  • Akabayov B, Lee SJ, Akabayov SR, Rekhi S, Zhu B, Richardson CC. DNA recognition by the DNA primase of bacteriophage T7: a structure-function study of the zinc-binding domain. Biochemistry. 2009;48(8):1763-73. doi: 10.1021/bi802123t. PubMed PMID: 19206208; PubMed Central PMCID: PMC2880633.
  • Alvarado JJ, Nemkal A, Sauder JM, Russell M, Akiyoshi DE, Shi W, et al. Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470. Molecular and biochemical parasitology. 2009;168(2):158-67. doi: 10.1016/j.molbiopara.2009.07.008. PubMed PMID: 19660503; PubMed Central PMCID: PMC2759695.
  • Breece RM, Hu Z, Bennett B, Crowder MW, Tierney DL. Motion of the zinc ions in catalysis by a dizinc metallo-beta-lactamase. Journal of the American Chemical Society. 2009;131(33):11642-3. doi: 10.1021/ja902534b. PubMed PMID: 19653676; PubMed Central PMCID: PMC3571662.
  • Campos-Bermudez VA, Gonzalez JM, Tierney DL, Vila AJ. Spectroscopic signature of a ubiquitous metal binding site in the metallo-beta-lactamase superfamily. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2010;15(8):1209-18. doi: 10.1007/s00775-010-0678-2. PubMed PMID: 20535505.
  • Catalano VJ, Moore AL, Shearer J, Kim J. Luminescent copper(I) halide butterfly dimers coordinated to [Au(CH3imCH2py)2]BF4 and [Au(CH3imCH2quin)2]BF4. Inorganic chemistry. 2009;48(23):11362-75. doi: 10.1021/ic901914n. PubMed PMID: 19899779.
  • England J, Martinho M, Farquhar ER, Frisch JR, Bominaar EL, Munck E, et al. A synthetic high-spin oxoiron(IV) complex: generation, spectroscopic characterization, and reactivity. Angewandte Chemie. 2009;48(20):3622-6. doi: 10.1002/anie.200900863. PubMed PMID: 19373820; PubMed Central PMCID: PMC2719303.
  • Frisch JR, Vu VV, Martinho M, Munck E, Que L, Jr. Characterization of two distinct adducts in the reaction of a nonheme diiron(II) complex with O2. Inorganic chemistry. 2009;48(17):8325-36. doi: 10.1021/ic900961k. PubMed PMID: 19610611; PubMed Central PMCID: PMC2846601.
  • Hawk MJ, Breece RM, Hajdin CE, Bender KM, Hu Z, Costello AL, et al. Differential binding of Co(II) and Zn(II) to metallo-beta-lactamase Bla2 from Bacillus anthracis. Journal of the American Chemical Society. 2009;131(30):10753-62. doi: 10.1021/ja900296u. PubMed PMID: 19588962; PubMed Central PMCID: PMC3295577.
  • Herbst RW, Guce A, Bryngelson PA, Higgins KA, Ryan KC, Cabelli DE, et al. Role of conserved tyrosine residues in NiSOD catalysis: a case of convergent evolution. Biochemistry. 2009;48(15):3354-69. doi: 10.1021/bi802029t. PubMed PMID: 19183068; PubMed Central PMCID: PMC3690555.
  • Kandegedara A, Thiyagarajan S, Kondapalli KC, Stemmler TL, Rosen BP. Role of bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor. The Journal of biological chemistry. 2009;284(22):14958-65. doi: 10.1074/jbc.M809179200. PubMed PMID: 19286656; PubMed Central PMCID: PMC2685678.
  • Kumar RS, Rekhi S, Prabhakaran D, Somayazulu M, Kim E, Cook JD, et al. Structural studies on Na0.75CoO2 thermoelectric material at high pressures. Solid State Commun. 2009;149(39-40):1712-6. doi: DOI 10.1016/j.ssc.2009.06.012. PubMed PMID: WOS:000270128700031.
  • Li H, Mapolelo DT, Dingra NN, Naik SG, Lees NS, Hoffman BM, et al. The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation. Biochemistry. 2009;48(40):9569-81. doi: 10.1021/bi901182w. PubMed PMID: 19715344; PubMed Central PMCID: PMC2796373.
  • Ramaswamy N, Arruda TM, Wen W, Hakim N, Saha M, Gulla A, et al. Enhanced activity and interfacial durability study of ultra low Pt based electrocatalysts prepared by ion beam assisted deposition (IBAD) method. Electrochim Acta. 2009;54(26):6756-66. doi: DOI 10.1016/j.electacta.2009.06.040. PubMed PMID: WOS:000270646600090.
  • Shearer J, Neupane KP, Callan PE. Metallopeptide based mimics with substituted histidines approximate a key hydrogen bonding network in the metalloenzyme nickel superoxide dismutase. Inorganic chemistry. 2009;48(22):10560-71. doi: 10.1021/ic9010407. PubMed PMID: 19894770; PubMed Central PMCID: PMC2778858.
  • Vu VV, Emerson JP, Martinho M, Kim YS, Munck E, Park MH, et al. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(35):14814-9. doi: 10.1073/pnas.0904553106. PubMed PMID: 19706422; PubMed Central PMCID: PMC2736468.
2008
  • Abriata LA, Gonzalez LJ, Llarrull LI, Tomatis PE, Myers WK, Costello AL, et al. Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase BcII are inactive. Biochemistry. 2008;47(33):8590-9. doi: 10.1021/bi8006912. PubMed PMID: 18652482; PubMed Central PMCID: PMC2565585.
  • Fiedler AT, Shan X, Mehn MP, Kaizer J, Torelli S, Frisch JR, et al. Spectroscopic and computational studies of (mu-oxo)(mu-1,2-peroxo)diiron(III) complexes of relevance to nonheme diiron oxygenase intermediates. The journal of physical chemistry A. 2008;112(50):13037-44. doi: 10.1021/jp8038225. PubMed PMID: 18811130; PubMed Central PMCID: PMC2736334.
  • Hakemian AS, Kondapalli KC, Telser J, Hoffman BM, Stemmler TL, Rosenzweig AC. The metal centers of particulate methane monooxygenase from Methylosinus trichosporium OB3b. Biochemistry. 2008;47(26):6793-801. doi: 10.1021/bi800598h. PubMed PMID: 18540635; PubMed Central PMCID: PMC2664655.
  • Hirota S, Kawahara T, Beltramini M, Di Muro P, Magliozzo RS, Peisach J, et al. Molecular basis of the Bohr effect in arthropod hemocyanin. The Journal of biological chemistry. 2008;283(46):31941-8. doi: 10.1074/jbc.M803433200. PubMed PMID: 18725416; PubMed Central PMCID: PMC2581592.
  • Jackson TA, Rohde JU, Seo MS, Sastri CV, DeHont R, Stubna A, et al. Axial ligand effects on the geometric and electronic structures of nonheme oxoiron(IV) complexes. Journal of the American Chemical Society. 2008;130(37):12394-407. doi: 10.1021/ja8022576. PubMed PMID: 18712873; PubMed Central PMCID: PMC2574688.
  • Kondapalli KC, Kok NM, Dancis A, Stemmler TL. Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly. Biochemistry. 2008;47(26):6917-27. doi: 10.1021/bi800366d. PubMed PMID: 18540637; PubMed Central PMCID: PMC2664653.
  • Ordonez E, Thiyagarajan S, Cook JD, Stemmler TL, Gil JA, Mateos LM, et al. Evolution of metal(loid) binding sites in transcriptional regulators. The Journal of biological chemistry. 2008;283(37):25706-14. doi: 10.1074/jbc.M803209200. PubMed PMID: 18591244; PubMed Central PMCID: PMC2533085.
  • Sagi I, Milla ME. Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme. Analytical biochemistry. 2008;372(1):1-10. doi: 10.1016/j.ab.2007.07.037. PubMed PMID: 17963710; PubMed Central PMCID: PMC2254313.
  • Shearer J, Soh P, Lentz S. Both Met(109) and Met(112) are utilized for Cu(II) coordination by the amyloidogenic fragment of the human prion protein at physiological pH. Journal of inorganic biochemistry. 2008;102(12):2103-13. doi: 10.1016/j.jinorgbio.2008.07.016. PubMed PMID: 18778855; PubMed Central PMCID: PMC2657601.
  • Shearer J, Szalai VA. The amyloid-beta peptide of Alzheimer's disease binds Cu(I) in a linear bis-his coordination environment: insight into a possible neuroprotective mechanism for the amyloid-beta peptide. Journal of the American Chemical Society. 2008;130(52):17826-35. doi: 10.1021/ja805940m. PubMed PMID: 19035781; PubMed Central PMCID: PMC2935688.
  • Shi W, Chance MR. Metallomics and metalloproteomics. Cellular and molecular life sciences : CMLS. 2008;65(19):3040-8. doi: 10.1007/s00018-008-8189-9. PubMed PMID: 18560755.
  • Smith SR, Bencze KZ, Wasiukanis K, Stemmler TL, Benore-Parsons M. Association of Copper to Riboflavin Binding Protein; Characterization by EPR and XAS. Open inorganic chemistry journal. 2008;2(3):22-4. doi: 10.2174/1874098700802010022. PubMed PMID: 19337565; PubMed Central PMCID: PMC2662589.
  • Solomon A, Selzer, T., Milla, M. Sagi, I. Biophysics and chemistry of metalloproteinases. Wiley Encyclopedia of Chemical Biology 2008.
Theses
  • Farmand M. X-ray Absorption Spectroscopy Characterization of Electrochemical Processes in Renewable Energy Storage and Conversion Devices: George Washington University; 2013.
  • Song H. Characterization of transition metals binding to carbonic anhydrase: Mississippi State University; 2013.
  • Bourassa M. The Involvement of Metal Ions in Copper-Zinc Superoxide Dismutase Related Amyotrophic Lateral Sclerosis [Ph.D.]2012.
  • Callan PE. X-ray Spectroscopic Studies of Model Compounds With Relevance to Nickel Superoxide Dismutase, Nitrile Hydratase and Copper Related Neurodegenerative Disorders [Ph.D.]2012.
  • Higgins KA. Metal Selectivity In The E. Coli Ni(II)- AND Co(II)-Responsive Transcriptional Regulator, RcnR [Ph.D.]2012.
  • Breece RM. Structural Characterization of Metal Binding in Metallo-.-lactamases using X-ray Absorption Spectroscopy [Ph.D.]2011.
  • Dai Z. The Molecular Basis of Diatomic Molecule Binding by H-NOX Domains [Ph.D.]2011.
  • Li F. Biomimetic Studies for Dioxygen Activation at Nonheme Iron Centers: University of Minnesota; 2011.
  • Vu V, V. Oxygen Activation by Novel Nonheme Diiron Enzymes [Ph.D.]2011.
  • Cook J. Frataxin, the Mitochondrial Iron Chaperone for Mitochondrial Fe-S Cluster Bioassembly [Ph.D.]2010.
  • Farquhar ER. Metal Substitution Studies of an Extradiol Dioxygenase and X-Ray Absorption Studies of High-Valent Nonheme Iron Complexes [Ph.D.]2010.
  • Herbst R. Structure and Function in a Nickel Metallochaperone, HypA and Nickel Dependent Superoxide Dismutase [Ph.D.]2010.
  • Arruda T. X-ray Absorption Spectroscopy Investigations into the Stability and Activity of Fuel Cell Electrocatalysts [Ph.D.]2009.
  • Neupane KP. Metallopeptide Based Models of Nickel Superoxide Dismutase [Ph.D.]2009.
  • Soh Fri P. Metal Binding to Peptide Fragments Derived From the Neurotoxic Domain of the Human Prion Protein [Ph.D.]2009.

X29A - Crystallography (Core C)

2013
  • Batra J, Szabo A, Caulfield TR, Soares AS, Sahin-Toth M, Radisky ES. Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. The Journal of biological chemistry. 2013;288(14):9848-59. doi: 10.1074/jbc.M113.457382. PubMed PMID: 23430245; PubMed Central PMCID: PMC3617285.
  • Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O. Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1. PloS one. 2013;8(2):e53819. doi: 10.1371/journal.pone.0053819. PubMed PMID: 23457445; PubMed Central PMCID: PMC3566133.
  • Buchko GW, Abendroth J, Robinson H, Zhang Y, Hewitt SN, Edwards TE, et al. Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia. Journal of structural and functional genomics. 2013;14(2):47-57. doi: 10.1007/s10969-013-9155-9. PubMed PMID: 23709284.
  • Cao Y, Pan Y, Huang H, Jin X, Levin EJ, Kloss B, et al. Gating of the TrkH ion channel by its associated RCK protein TrkA. Nature. 2013;496(7445):317-22. doi: 10.1038/nature12056. PubMed PMID: 23598339; PubMed Central PMCID: PMC3726529.
  • Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ. RAC1P29S is a spontaneously activating cancer-associated GTPase. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(3):912-7. doi: 10.1073/pnas.1220895110. PubMed PMID: 23284172; PubMed Central PMCID: PMC3549122.
  • Deng L, Zhong L, Struble E, Duan H, Ma L, Harman C, et al. Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(18):7418-22. doi: 10.1073/pnas.1305306110. PubMed PMID: 23589879; PubMed Central PMCID: PMC3645581.
  • Fisher OS, Zhang R, Li X, Murphy JW, Demeler B, Boggon TJ. Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus. FEBS letters. 2013;587(3):272-7. doi: 10.1016/j.febslet.2012.12.011. PubMed PMID: 23266514; PubMed Central PMCID: PMC3558538.
  • Haapalainen AM, Thomas K, Tyler PC, Evans GB, Almo SC, Schramm VL. Salmonella enterica MTAN at 1.36 A Resolution: A Structure-Based Design of Tailored Transition State Analogs. Structure. 2013;21(6):963-74. doi: 10.1016/j.str.2013.04.009. PubMed PMID: 23685211; PubMed Central PMCID: PMC3690532.
  • Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, et al. Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity. PloS one. 2013;8(2):e57008. doi: 10.1371/journal.pone.0057008. PubMed PMID: 23451136; PubMed Central PMCID: PMC3581573.
  • Hsu HC, Wang CL, Wang M, Yang N, Chen Z, Sternglanz R, et al. Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding. Genes & development. 2013;27(1):64-73. doi: 10.1101/gad.208140.112. PubMed PMID: 23307867; PubMed Central PMCID: PMC3553284.
  • Janjusevic R, Quezada CM, Small J, Stebbins CE. Structure of the HopA1(21-102)-ShcA chaperone-effector complex of Pseudomonas syringae reveals conservation of a virulence factor binding motif from animal to plant pathogens. Journal of bacteriology. 2013;195(4):658-64. doi: 10.1128/JB.01621-12. PubMed PMID: 23204470; PubMed Central PMCID: PMC3562103.
  • Karpowich NK, Wang DN. Assembly and mechanism of a group II ECF transporter. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(7):2534-9. doi: 10.1073/pnas.1217361110. PubMed PMID: 23359690; PubMed Central PMCID: PMC3574940.
  • Kellett WF, Brunk E, Desai BJ, Fedorov AA, Almo SC, Gerlt JA, et al. Computational, structural, and kinetic evidence that Vibrio vulnificus FrsA is not a cofactor-independent pyruvate decarboxylase. Biochemistry. 2013;52(11):1842-4. doi: 10.1021/bi400093y. PubMed PMID: 23452154.
  • Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP. Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT. The Journal of biological chemistry. 2013;288(15):10188-94. doi: 10.1074/jbc.C113.451369. PubMed PMID: 23417676; PubMed Central PMCID: PMC3624403.
  • Kuroda DG, Bauman JD, Challa JR, Patel D, Troxler T, Das K, et al. Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nature chemistry. 2013;5(3):174-81. doi: 10.1038/nchem.1559. PubMed PMID: 23422558; PubMed Central PMCID: PMC3607437.
  • Langelier MF, Pascal JM. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis. Current opinion in structural biology. 2013;23(1):134-43. doi: 10.1016/j.sbi.2013.01.003. PubMed PMID: 23333033; PubMed Central PMCID: PMC3572337.
  • Leonard PG, Golemi-Kotra D, Stock AM. Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(21):8525-30. doi: 10.1073/pnas.1302819110. PubMed PMID: 23650349; PubMed Central PMCID: PMC3666669.
  • Li H, Jogl G. Crystal structure of decaprenylphosphoryl-beta- D-ribose 2'-epimerase from Mycobacterium smegmatis. Proteins. 2013;81(3):538-43. doi: 10.1002/prot.24220. PubMed PMID: 23184707; PubMed Central PMCID: PMC3557725.
  • Liu W, Boggon TJ. Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide. Acta crystallographica Section F, Structural biology and crystallization communications. 2013;69(Pt 5):494-8. doi: 10.1107/S1744309113010762. PubMed PMID: 23695561; PubMed Central PMCID: PMC3660885.
  • Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ. Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Molecular cell. 2013;49(4):719-29. doi: 10.1016/j.molcel.2012.12.005. PubMed PMID: 23317506; PubMed Central PMCID: PMC3684052.
  • Lokareddy RK, Bhardwaj A, Cingolani G. Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. Biochemistry. 2013;52(5):938-48. doi: 10.1021/bi301476m. PubMed PMID: 23298255; PubMed Central PMCID: PMC3619938.
  • Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, et al. A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules. Molecular immunology. 2013;55(2):123-5. doi: 10.1016/j.molimm.2012.10.021. PubMed PMID: 23200143; PubMed Central PMCID: PMC3632263.
  • Mason M, Wanat JJ, Harper S, Schultz DC, Speicher DW, Johnson FB, et al. Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance. Structure. 2013;21(1):109-20. doi: 10.1016/j.str.2012.10.012. PubMed PMID: 23177925; PubMed Central PMCID: PMC3545062.
  • Meinke G, Phelan PJ, Harrison CJ, Bullock PA. Analysis of the costructure of the simian virus 40 T-antigen origin binding domain with site I reveals a correlation between GAGGC spacing and spiral assembly. Journal of virology. 2013;87(5):2923-34. doi: 10.1128/JVI.02549-12. PubMed PMID: 23269808; PubMed Central PMCID: PMC3571380.
  • Oh YS, Gao P, Lee KW, Ceglia I, Seo JS, Zhang X, et al. SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action. Cell. 2013;152(4):831-43. doi: 10.1016/j.cell.2013.01.014. PubMed PMID: 23415230; PubMed Central PMCID: PMC3633087.
  • Olsen SK, Lima CD. Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Molecular cell. 2013;49(5):884-96. doi: 10.1016/j.molcel.2013.01.013. PubMed PMID: 23416107; PubMed Central PMCID: PMC3625138.
  • Solmaz SR, Blobel G, Melcak I. Ring cycle for dilating and constricting the nuclear pore. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(15):5858-63. doi: 10.1073/pnas.1302655110. PubMed PMID: 23479651; PubMed Central PMCID: PMC3625290.
  • Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, et al. Catalytic site conformations in human PNP by 19F-NMR and crystallography. Chemistry & biology. 2013;20(2):212-22. doi: 10.1016/j.chembiol.2013.01.009. PubMed PMID: 23438750; PubMed Central PMCID: PMC3584414.
  • Swiercz JP, Nanji T, Gloyd M, Guarne A, Elliot MA. A novel nucleoid-associated protein specific to the actinobacteria. Nucleic acids research. 2013;41(7):4171-84. doi: 10.1093/nar/gkt095. PubMed PMID: 23427309; PubMed Central PMCID: PMC3627587.
  • Tan D, Marzluff WF, Dominski Z, Tong L. Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex. Science. 2013;339(6117):318-21. doi: 10.1126/science.1228705. PubMed PMID: 23329046; PubMed Central PMCID: PMC3552377.
  • Weixlbaumer A, Leon K, Landick R, Darst SA. Structural basis of transcriptional pausing in bacteria. Cell. 2013;152(3):431-41. doi: 10.1016/j.cell.2012.12.020. PubMed PMID: 23374340; PubMed Central PMCID: PMC3564060.
  • Yu LP, Chou CY, Choi PH, Tong L. Characterizing the importance of the biotin carboxylase domain dimer for Staphylococcus aureus pyruvate carboxylase catalysis. Biochemistry. 2013;52(3):488-96. doi: 10.1021/bi301294d. PubMed PMID: 23286247; PubMed Central PMCID: PMC3553216.
  • Zhang Y, Gardberg AS, Edwards TE, Sankaran B, Robinson H, Varnum SM, et al. Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D. Biochimie. 2013;95(7):1379-85. doi: 10.1016/j.biochi.2013.03.006. PubMed PMID: 23523511; PubMed Central PMCID: PMC3674139.
2012
  • Andres SN, Vergnes A, Ristic D, Wyman C, Modesti M, Junop M. A human XRCC4-XLF complex bridges DNA. Nucleic acids research. 2012;40(4):1868-78. doi: 10.1093/nar/gks022. PubMed PMID: 22287571; PubMed Central PMCID: PMC3287209.
  • Armstrong AA, Mohideen F, Lima CD. Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature. 2012;483(7387):59-63. doi: 10.1038/nature10883. PubMed PMID: 22382979; PubMed Central PMCID: PMC3306252.
  • Ashwell MA, Lapierre JM, Brassard C, Bresciano K, Bull C, Cornell-Kennon S, et al. Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. Journal of medicinal chemistry. 2012;55(11):5291-310. doi: 10.1021/jm300276x. PubMed PMID: 22533986.
  • Berke IC, Modis Y. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. The EMBO journal. 2012;31(7):1714-26. doi: 10.1038/emboj.2012.19. PubMed PMID: 22314235; PubMed Central PMCID: PMC3321199.
  • Bhaskaran SS, Stebbins CE. Structure of the catalytic domain of the Salmonella virulence factor SseI. Acta crystallographica Section D, Biological crystallography. 2012;68(Pt 12):1613-21. doi: 10.1107/S0907444912039042. PubMed PMID: 23151626; PubMed Central PMCID: PMC3498931.
  • Bulkley D, Johnson F, Steitz TA. The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome. Journal of molecular biology. 2012;416(4):571-8. doi: 10.1016/j.jmb.2011.12.055. PubMed PMID: 22240456; PubMed Central PMCID: PMC3336878.
  • Cappadocia L, Parent JS, Zampini E, Lepage E, Sygusch J, Brisson N. A conserved lysine residue of plant Whirly proteins is necessary for higher order protein assembly and protection against DNA damage. Nucleic acids research. 2012;40(1):258-69. doi: 10.1093/nar/gkr740. PubMed PMID: 21911368; PubMed Central PMCID: PMC3245945.
  • Chen M, Drury JE, Christianson DW, Penning TM. Conversion of human steroid 5beta-reductase (AKR1D1) into 3beta-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering. The Journal of biological chemistry. 2012;287(20):16609-22. doi: 10.1074/jbc.M111.338780. PubMed PMID: 22437839; PubMed Central PMCID: PMC3351325.
  • Cheung J, Rudolph MJ, Burshteyn F, Cassidy MS, Gary EN, Love J, et al. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. Journal of medicinal chemistry. 2012;55(22):10282-6. doi: 10.1021/jm300871x. PubMed PMID: 23035744.
  • Chung YS, Guarne A. Iterative optimization of DNA duplexes for crystallization of SeqA-DNA complexes. Journal of visualized experiments : JoVE. 2012(69):e4266. doi: 10.3791/4266. PubMed PMID: 23149570.
  • Cockrell GM, Kantrowitz ER. Metal ion involvement in the allosteric mechanism of Escherichia coli aspartate transcarbamoylase. Biochemistry. 2012;51(36):7128-37. doi: 10.1021/bi300920m. PubMed PMID: 22906065; PubMed Central PMCID: PMC3461825.
  • D'Antonio EL, Christianson DW. Binding of the unreactive substrate analog L-2-amino-3-guanidinopropionic acid (dinor-L-arginine) to human arginase I. Acta crystallographica Section F, Structural biology and crystallization communications. 2012;68(Pt 8):889-93. doi: 10.1107/S1744309112027820. PubMed PMID: 22869115; PubMed Central PMCID: PMC3412766.
  • D'Antonio EL, Hai Y, Christianson DW. Structure and function of non-native metal clusters in human arginase I. Biochemistry. 2012;51(42):8399-409. doi: 10.1021/bi301145n. PubMed PMID: 23061982; PubMed Central PMCID: PMC3490219.
  • Desai BJ, Wood BM, Fedorov AA, Fedorov EV, Goryanova B, Amyes TL, et al. Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry. 2012;51(43):8665-78. doi: 10.1021/bi301188k. PubMed PMID: 23030629; PubMed Central PMCID: PMC3549026.
  • Dessau M, Goldhill D, McBride R, Turner PE, Modis Y. Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzyme. PLoS genetics. 2012;8(11):e1003102. doi: 10.1371/journal.pgen.1003102. PubMed PMID: 23209446; PubMed Central PMCID: PMC3510033.
  • Du J, Kelly AE, Funabiki H, Patel DJ. Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure. 2012;20(1):185-95. doi: 10.1016/j.str.2011.12.001. PubMed PMID: 22244766; PubMed Central PMCID: PMC3684423.
  • Duclos S, Aller P, Jaruga P, Dizdaroglu M, Wallace SS, Doublie S. Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. DNA repair. 2012;11(9):714-25. doi: 10.1016/j.dnarep.2012.06.004. PubMed PMID: 22789755; PubMed Central PMCID: PMC3419285.
  • Elkayam E, Kuhn CD, Tocilj A, Haase AD, Greene EM, Hannon GJ, et al. The structure of human argonaute-2 in complex with miR-20a. Cell. 2012;150(1):100-10. doi: 10.1016/j.cell.2012.05.017. PubMed PMID: 22682761; PubMed Central PMCID: PMC3464090.
  • Frey KM, Bollini M, Mislak AC, Cisneros JA, Gallardo-Macias R, Jorgensen WL, et al. Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design. Journal of the American Chemical Society. 2012;134(48):19501-3. doi: 10.1021/ja3092642. PubMed PMID: 23163887; PubMed Central PMCID: PMC3518392.
  • Gagnon MG, Seetharaman SV, Bulkley D, Steitz TA. Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science. 2012;335(6074):1370-2. doi: 10.1126/science.1217443. PubMed PMID: 22422986; PubMed Central PMCID: PMC3377438.
  • Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nature chemical biology. 2012;8(4):366-74. doi: 10.1038/nchembio.792. PubMed PMID: 22344177; PubMed Central PMCID: PMC3307835.
  • Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. The Journal of biological chemistry. 2012;287(28):23790-807. doi: 10.1074/jbc.M112.361550. PubMed PMID: 22605381; PubMed Central PMCID: PMC3390653.
  • Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorganic & medicinal chemistry letters. 2012;22(21):6636-41. doi: 10.1016/j.bmcl.2012.08.107. PubMed PMID: 23021994.
  • Guan R, Ho MC, Frohlich RF, Tyler PC, Almo SC, Schramm VL. Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry. 2012;51(45):9094-103. doi: 10.1021/bi301062y. PubMed PMID: 23050701; PubMed Central PMCID: PMC3567251.
  • Guja KE, Garcia-Diaz M. Hitting the brakes: termination of mitochondrial transcription. Biochimica et biophysica acta. 2012;1819(9-10):939-47. doi: 10.1016/j.bbagrm.2011.11.004. PubMed PMID: 22137970; PubMed Central PMCID: PMC3408806.
  • Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, et al. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(40):16107-12. doi: 10.1073/pnas.1214447109. PubMed PMID: 22988085; PubMed Central PMCID: PMC3479536.
  • Han Y, Whitney G, Donovan J, Korennykh A. Innate immune messenger 2-5A tethers human RNase L into active high-order complexes. Cell reports. 2012;2(4):902-13. doi: 10.1016/j.celrep.2012.09.004. PubMed PMID: 23084743.
  • Hou X, Pedi L, Diver MM, Long SB. Crystal structure of the calcium release-activated calcium channel Orai. Science. 2012;338(6112):1308-13. doi: 10.1126/science.1228757. PubMed PMID: 23180775; PubMed Central PMCID: PMC3695727.
  • Huang CS, Ge P, Zhou ZH, Tong L. An unanticipated architecture of the 750-kDa alpha6beta6 holoenzyme of 3-methylcrotonyl-CoA carboxylase. Nature. 2012;481(7380):219-23. doi: 10.1038/nature10691. PubMed PMID: 22158123; PubMed Central PMCID: PMC3271731.
  • Itsathitphaisarn O, Wing RA, Eliason WK, Wang J, Steitz TA. The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell. 2012;151(2):267-77. doi: 10.1016/j.cell.2012.09.014. PubMed PMID: 23022319; PubMed Central PMCID: PMC3597440.
  • Jauch R, Ng CK, Narasimhan K, Kolatkar PR. The crystal structure of the Sox4 HMG domain-DNA complex suggests a mechanism for positional interdependence in DNA recognition. The Biochemical journal. 2012;443(1):39-47. doi: 10.1042/BJ20111768. PubMed PMID: 22181698.
  • Jiang J, Lazarus MB, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nature chemical biology. 2012;8(1):72-7. doi: 10.1038/nchembio.711. PubMed PMID: 22082911; PubMed Central PMCID: PMC3241908.
  • Jin H, Zhang Y, Buchko GW, Varnum SM, Robinson H, Squier TC, et al. Structure determination and functional analysis of a chromate reductase from Gluconacetobacter hansenii. PloS one. 2012;7(8):e42432. doi: 10.1371/journal.pone.0042432. PubMed PMID: 22879982; PubMed Central PMCID: PMC3412864.
  • Jing X, Robinson HR, Heffron JD, Popham DL, Schubot FD. The catalytic domain of the germination-specific lytic transglycosylase SleB from Bacillus anthracis displays a unique active site topology. Proteins. 2012;80(10):2469-75. doi: 10.1002/prot.24140. PubMed PMID: 22777830; PubMed Central PMCID: PMC3621120.
  • Ke W, Laurent AH, Armstrong MD, Chen Y, Smith WE, Liang J, et al. Structure of an engineered beta-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation. PloS one. 2012;7(6):e39168. doi: 10.1371/journal.pone.0039168. PubMed PMID: 22720063; PubMed Central PMCID: PMC3375305.
  • Korennykh A, Walter P. Structural basis of the unfolded protein response. Annual review of cell and developmental biology. 2012;28:251-77. doi: 10.1146/annurev-cellbio-101011-155826. PubMed PMID: 23057742.
  • Kumar G, Kumaran D, Ahmed SA, Swaminathan S. Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling. Acta crystallographica Section D, Biological crystallography. 2012;68(Pt 5):511-20. doi: 10.1107/S0907444912003551. PubMed PMID: 22525749.
  • Langelier MF, Planck JL, Roy S, Pascal JM. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science. 2012;336(6082):728-32. doi: 10.1126/science.1216338. PubMed PMID: 22582261; PubMed Central PMCID: PMC3532513.
  • Lazarus MB, Jiang J, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, et al. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nature chemical biology. 2012;8(12):966-8. doi: 10.1038/nchembio.1109. PubMed PMID: 23103939; PubMed Central PMCID: PMC3508357.
  • Levin EJ, Cao Y, Enkavi G, Quick M, Pan Y, Tajkhorshid E, et al. Structure and permeation mechanism of a mammalian urea transporter. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(28):11194-9. doi: 10.1073/pnas.1207362109. PubMed PMID: 22733730; PubMed Central PMCID: PMC3396522.
  • Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ. Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). The Journal of biological chemistry. 2012;287(26):22317-27. doi: 10.1074/jbc.M112.361295. PubMed PMID: 22577140; PubMed Central PMCID: PMC3381192.
  • Li Y, Jin K, Setlow B, Setlow P, Hao B. Crystal structure of the catalytic domain of the Bacillus cereus SleB protein, important in cortex peptidoglycan degradation during spore germination. Journal of bacteriology. 2012;194(17):4537-45. doi: 10.1128/JB.00877-12. PubMed PMID: 22730118; PubMed Central PMCID: PMC3415495.
  • Liang Y, Choo SH, Rossbach M, Baburajendran N, Palasingam P, Kolatkar PR. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206. Acta crystallographica Section F, Structural biology and crystallization communications. 2012;68(Pt 4):443-7. doi: 10.1107/S1744309112006070. PubMed PMID: 22505416; PubMed Central PMCID: PMC3325816.
  • Little DJ, Poloczek J, Whitney JC, Robinson H, Nitz M, Howell PL. The structure- and metal-dependent activity of Escherichia coli PgaB provides insight into the partial de-N-acetylation of poly-beta-1,6-N-acetyl-D-glucosamine. The Journal of biological chemistry. 2012;287(37):31126-37. doi: 10.1074/jbc.M112.390005. PubMed PMID: 22810235; PubMed Central PMCID: PMC3438944.
  • Little DJ, Whitney JC, Robinson H, Yip P, Nitz M, Howell PL. Combining in situ proteolysis and mass spectrometry to crystallize Escherichia coli PgaB. Acta crystallographica Section F, Structural biology and crystallization communications. 2012;68(Pt 7):842-5. doi: 10.1107/S1744309112022075. PubMed PMID: 22750880; PubMed Central PMCID: PMC3388937.
  • Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, et al. The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. Journal of immunology. 2012;189(3):1391-9. doi: 10.4049/jimmunol.1200831. PubMed PMID: 22753930; PubMed Central PMCID: PMC3422668.
  • Mancusso R, Gregorio GG, Liu Q, Wang DN. Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter. Nature. 2012;491(7425):622-6. doi: 10.1038/nature11542. PubMed PMID: 23086149; PubMed Central PMCID: PMC3617922.
  • Manjasetty BA, Yu XH, Panjikar S, Taguchi G, Chance MR, Liu CJ. Structural basis for modification of flavonol and naphthol glucoconjugates by Nicotiana tabacum malonyltransferase (NtMaT1). Planta. 2012;236(3):781-93. doi: 10.1007/s00425-012-1660-8. PubMed PMID: 22610270.
  • Matthews LA, Jones DR, Prasad AA, Duncker BP, Guarne A. Saccharomyces cerevisiae Dbf4 has unique fold necessary for interaction with Rad53 kinase. The Journal of biological chemistry. 2012;287(4):2378-87. doi: 10.1074/jbc.M111.233973. PubMed PMID: 22130670; PubMed Central PMCID: PMC3268399.
  • McMahon C, Studer SM, Clendinen C, Dann GP, Jeffrey PD, Hughson FM. The structure of Sec12 implicates potassium ion coordination in Sar1 activation. The Journal of biological chemistry. 2012;287(52):43599-606. doi: 10.1074/jbc.M112.420141. PubMed PMID: 23109340; PubMed Central PMCID: PMC3527946.
  • Miller AN, Long SB. Crystal structure of the human two-pore domain potassium channel K2P1. Science. 2012;335(6067):432-6. doi: 10.1126/science.1213274. PubMed PMID: 22282804.
  • Miner KD, Mukherjee A, Gao YG, Null EL, Petrik ID, Zhao X, et al. A designed functional metalloenzyme that reduces O2 to H2O with over one thousand turnovers. Angewandte Chemie. 2012;51(23):5589-92. doi: 10.1002/anie.201201981. PubMed PMID: 22539151; PubMed Central PMCID: PMC3461324.
  • Osborne SE, Tuinema BR, Mok MC, Lau PS, Bui NK, Tomljenovic-Berube AM, et al. Characterization of DalS, an ATP-binding cassette transporter for D-alanine, and its role in pathogenesis in Salmonella enterica. The Journal of biological chemistry. 2012;287(19):15242-50. doi: 10.1074/jbc.M112.348227. PubMed PMID: 22418438; PubMed Central PMCID: PMC3346123.
  • Paulson AR, Tong L. Crystal structure of the Rna14-Rna15 complex. Rna. 2012;18(6):1154-62. doi: 10.1261/rna.032524.112. PubMed PMID: 22513198; PubMed Central PMCID: PMC3358638.
  • Polikanov YS, Blaha GM, Steitz TA. How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science. 2012;336(6083):915-8. doi: 10.1126/science.1218538. PubMed PMID: 22605777; PubMed Central PMCID: PMC3377384.
  • Roy A, Hutcheon ML, Duncan TM, Cingolani G. Improved crystallization of Escherichia coli ATP synthase catalytic complex (F1) by introducing a phosphomimetic mutation in subunit epsilon. Acta crystallographica Section F, Structural biology and crystallization communications. 2012;68(Pt 10):1229-33. doi: 10.1107/S1744309112036718. PubMed PMID: 23027754; PubMed Central PMCID: PMC3490465.
  • Senguen FT, Grabarek Z. X-ray structures of magnesium and manganese complexes with the N-terminal domain of calmodulin: insights into the mechanism and specificity of metal ion binding to an EF-hand. Biochemistry. 2012;51(31):6182-94. doi: 10.1021/bi300698h. PubMed PMID: 22803592; PubMed Central PMCID: PMC3448793.
  • Smith MA, Coincon M, Paschos A, Jolicoeur B, Lavallee P, Sygusch J, et al. Identification of the binding site of Brucella VirB8 interaction inhibitors. Chemistry & biology. 2012;19(8):1041-8. doi: 10.1016/j.chembiol.2012.07.007. PubMed PMID: 22921071.
  • Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, et al. Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. The Journal of biological chemistry. 2012;287(44):37371-82. doi: 10.1074/jbc.M112.367003. PubMed PMID: 22930756; PubMed Central PMCID: PMC3481334.
  • Stone CB, Sugiman-Marangos S, Bulir DC, Clayden RC, Leighton TL, Slootstra JW, et al. Structural characterization of a novel Chlamydia pneumoniae type III secretion-associated protein, Cpn0803. PloS one. 2012;7(1):e30220. doi: 10.1371/journal.pone.0030220. PubMed PMID: 22272312; PubMed Central PMCID: PMC3260263.
  • Thangavelu K, Pan CQ, Karlberg T, Balaji G, Uttamchandani M, Suresh V, et al. Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(20):7705-10. doi: 10.1073/pnas.1116573109. PubMed PMID: 22538822; PubMed Central PMCID: PMC3356676.
  • Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, et al. Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors. The Journal of biological chemistry. 2012;287(15):11788-97. doi: 10.1074/jbc.M111.326777. PubMed PMID: 22356915; PubMed Central PMCID: PMC3320927.
  • Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, et al. Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1gamma reveals a paradigm for MHC/MHC interaction in immune evasion. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(51):E3578-87. doi: 10.1073/pnas.1214088109. PubMed PMID: 23169621; PubMed Central PMCID: PMC3529088.
  • Wang S, Haapalainen AM, Yan F, Du Q, Tyler PC, Evans GB, et al. A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. Biochemistry. 2012;51(35):6892-4. doi: 10.1021/bi3009664. PubMed PMID: 22891633; PubMed Central PMCID: PMC3437630.
  • Whitney JC, Colvin KM, Marmont LS, Robinson H, Parsek MR, Howell PL. Structure of the cytoplasmic region of PelD, a degenerate diguanylate cyclase receptor that regulates exopolysaccharide production in Pseudomonas aeruginosa. The Journal of biological chemistry. 2012;287(28):23582-93. doi: 10.1074/jbc.M112.375378. PubMed PMID: 22605337; PubMed Central PMCID: PMC3390633.
  • Xu H, Hazra S, Blanchard JS. NXL104 irreversibly inhibits the beta-lactamase from Mycobacterium tuberculosis. Biochemistry. 2012;51(22):4551-7. doi: 10.1021/bi300508r. PubMed PMID: 22587688; PubMed Central PMCID: PMC3448018.
  • Yakubovskaya E, Guja KE, Mejia E, Castano S, Hambardjieva E, Choi WS, et al. Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification. Structure. 2012;20(11):1940-7. doi: 10.1016/j.str.2012.08.027. PubMed PMID: 23022348; PubMed Central PMCID: PMC3496059.
  • Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, et al. Cyclic di-GMP sensing via the innate immune signaling protein STING. Molecular cell. 2012;46(6):735-45. doi: 10.1016/j.molcel.2012.05.029. PubMed PMID: 22705373; PubMed Central PMCID: PMC3697849.
  • Yu X, Breitman M, Goldberg J. A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes. Cell. 2012;148(3):530-42. doi: 10.1016/j.cell.2012.01.015. PubMed PMID: 22304919; PubMed Central PMCID: PMC3285272.
  • Yuan P, Leonetti MD, Hsiung Y, MacKinnon R. Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature. 2012;481(7379):94-7. doi: 10.1038/nature10670. PubMed PMID: 22139424; PubMed Central PMCID: PMC3319005.
  • Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, et al. Structural basis for calmodulin as a dynamic calcium sensor. Structure. 2012;20(5):911-23. doi: 10.1016/j.str.2012.03.019. PubMed PMID: 22579256; PubMed Central PMCID: PMC3372094.
  • Zhang M, Pascal JM, Schumann M, Armen RS, Zhang JF. Identification of the functional binding pocket for compounds targeting small-conductance Ca(2)(+)-activated potassium channels. Nature communications. 2012;3:1021. doi: 10.1038/ncomms2017. PubMed PMID: 22929778; PubMed Central PMCID: PMC3563359.
  • Zhang Y, Feng Y, Chatterjee S, Tuske S, Ho MX, Arnold E, et al. Structural basis of transcription initiation. Science. 2012;338(6110):1076-80. doi: 10.1126/science.1227786. PubMed PMID: 23086998; PubMed Central PMCID: PMC3593053.
2011
  • Andres SN, Junop MS. Crystallization and preliminary X-ray diffraction analysis of the human XRCC4-XLF complex. Acta crystallographica Section F, Structural biology and crystallization communications. 2011;67(Pt 11):1399-402. doi: 10.1107/S1744309111033549. PubMed PMID: 22102241; PubMed Central PMCID: PMC3212460.
  • Bachega JF, Bleicher L, Horjales ER, Santiago PS, Garratt RC, Tabak M. Crystallization and preliminary structural analysis of the giant haemoglobin from Glossoscolex paulistus at 3.2 A. Journal of synchrotron radiation. 2011;18(1):24-8. doi: 10.1107/S090904951002772X. PubMed PMID: 21169685; PubMed Central PMCID: PMC3004248.
  • Brown JH, Kumar VS, O'Neall-Hennessey E, Reshetnikova L, Robinson H, Nguyen-McCarty M, et al. Visualizing key hinges and a potential major source of compliance in the lever arm of myosin. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(1):114-9. doi: 10.1073/pnas.1016288107. PubMed PMID: 21149681; PubMed Central PMCID: PMC3017161.
  • Butler EB, Xiong Y, Wang J, Strobel SA. Structural basis of cooperative ligand binding by the glycine riboswitch. Chemistry & biology. 2011;18(3):293-8. doi: 10.1016/j.chembiol.2011.01.013. PubMed PMID: 21439473; PubMed Central PMCID: PMC3076126.
  • Byrnes J, Garcia-Diaz M. Mitochondrial transcription: how does it end? Transcription. 2011;2(1):32-6. doi: 10.4161/trns.2.1.14006. PubMed PMID: 21326908; PubMed Central PMCID: PMC3023645.
  • Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, et al. Crystal structure of a potassium ion transporter, TrkH. Nature. 2011;471(7338):336-40. doi: 10.1038/nature09731. PubMed PMID: 21317882; PubMed Central PMCID: PMC3077569.
  • Cao Y, Jin X, Levin EJ, Huang H, Zong Y, Quick M, et al. Crystal structure of a phosphorylation-coupled saccharide transporter. Nature. 2011;473(7345):50-4. doi: 10.1038/nature09939. PubMed PMID: 21471968; PubMed Central PMCID: PMC3201810.
  • Cassera MB, Ho MC, Merino EF, Burgos ES, Rinaldo-Matthis A, Almo SC, et al. A high-affinity adenosine kinase from Anopheles gambiae. Biochemistry. 2011;50(11):1885-93. doi: 10.1021/bi101921w. PubMed PMID: 21247194; PubMed Central PMCID: PMC3059358.
  • Chang JH, Xiang S, Xiang K, Manley JL, Tong L. Structural and biochemical studies of the 5'-->3' exoribonuclease Xrn1. Nature structural & molecular biology. 2011;18(3):270-6. doi: 10.1038/nsmb.1984. PubMed PMID: 21297639; PubMed Central PMCID: PMC3075561.
  • Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, et al. A strategy for antagonizing quorum sensing. Molecular cell. 2011;42(2):199-209. doi: 10.1016/j.molcel.2011.04.003. PubMed PMID: 21504831; PubMed Central PMCID: PMC3092643.
  • Cho Y, Vermeire JJ, Merkel JS, Leng L, Du X, Bucala R, et al. Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chemistry & biology. 2011;18(9):1089-101. doi: 10.1016/j.chembiol.2011.07.011. PubMed PMID: 21944748; PubMed Central PMCID: PMC3294498.
  • Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, et al. Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. Journal of molecular biology. 2011;408(4):697-713. doi: 10.1016/j.jmb.2011.03.002. PubMed PMID: 21419780; PubMed Central PMCID: PMC3086336.
  • Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. Journal of the American Chemical Society. 2011;133(32):12474-7. doi: 10.1021/ja205972n. PubMed PMID: 21790156; PubMed Central PMCID: PMC3162211.
  • D'Antonio EL, Christianson DW. Crystal structures of complexes with cobalt-reconstituted human arginase I. Biochemistry. 2011;50(37):8018-27. doi: 10.1021/bi201101t. PubMed PMID: 21870783; PubMed Central PMCID: PMC3172387.
  • Eathiraj S, Palma R, Hirschi M, Volckova E, Nakuci E, Castro J, et al. A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. The Journal of biological chemistry. 2011;286(23):20677-87. doi: 10.1074/jbc.M110.213736. PubMed PMID: 21454610; PubMed Central PMCID: PMC3121527.
  • Eathiraj S, Palma R, Volckova E, Hirschi M, France DS, Ashwell MA, et al. Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197. The Journal of biological chemistry. 2011;286(23):20666-76. doi: 10.1074/jbc.M110.213801. PubMed PMID: 21454604; PubMed Central PMCID: PMC3121448.
  • Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, et al. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nature structural & molecular biology. 2011;18(3):316-22. doi: 10.1038/nsmb.2007. PubMed PMID: 21336276; PubMed Central PMCID: PMC3101628.
  • Feklistov A, Darst SA. Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell. 2011;147(6):1257-69. doi: 10.1016/j.cell.2011.10.041. PubMed PMID: 22136875; PubMed Central PMCID: PMC3245737.
  • Gloyd M, Ghirlando R, Guarne A. The role of MukE in assembling a functional MukBEF complex. Journal of molecular biology. 2011;412(4):578-90. doi: 10.1016/j.jmb.2011.08.009. PubMed PMID: 21855551; PubMed Central PMCID: PMC3482342.
  • Guan R, Ho MC, Brenowitz M, Tyler PC, Evans GB, Almo SC, et al. Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase. Biochemistry. 2011;50(47):10408-17. doi: 10.1021/bi201321x. PubMed PMID: 21985704; PubMed Central PMCID: PMC3222737.
  • Hansen SB, Tao X, MacKinnon R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature. 2011;477(7365):495-8. doi: 10.1038/nature10370. PubMed PMID: 21874019; PubMed Central PMCID: PMC3324908.
  • Harris KM, Cockrell GM, Puleo DE, Kantrowitz ER. Crystallographic snapshots of the complete catalytic cycle of the unregulated aspartate transcarbamoylase from Bacillus subtilis. Journal of molecular biology. 2011;411(1):190-200. doi: 10.1016/j.jmb.2011.05.036. PubMed PMID: 21663747; PubMed Central PMCID: PMC3211067.
  • Harrison CJ, Meinke G, Kwun HJ, Rogalin H, Phelan PJ, Bullock PA, et al. Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. Journal of molecular biology. 2011;409(4):529-42. doi: 10.1016/j.jmb.2011.03.051. PubMed PMID: 21501625; PubMed Central PMCID: PMC3104116.
  • Huang H, Patskovsky Y, Toro R, Farelli JD, Pandya C, Almo SC, et al. Divergence of structure and function in the haloacid dehalogenase enzyme superfamily: Bacteroides thetaiotaomicron BT2127 is an inorganic pyrophosphatase. Biochemistry. 2011;50(41):8937-49. doi: 10.1021/bi201181q. PubMed PMID: 21894910; PubMed Central PMCID: PMC3342813.
  • Huang KY, Amodeo GA, Tong L, McDermott A. The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. Protein science : a publication of the Protein Society. 2011;20(3):630-9. doi: 10.1002/pro.584. PubMed PMID: 21432937; PubMed Central PMCID: PMC3064841.
  • Jackson S, Sugiman-Marangos S, Cheung K, Junop M. Crystallization and preliminary diffraction analysis of truncated human pleckstrin. Acta crystallographica Section F, Structural biology and crystallization communications. 2011;67(Pt 3):412-6. doi: 10.1107/S174430911005092X. PubMed PMID: 21393855; PubMed Central PMCID: PMC3053175.
  • Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M, Jr., Patel SS, et al. Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature. 2011;479(7373):423-7. doi: 10.1038/nature10537. PubMed PMID: 21947008; PubMed Central PMCID: PMC3430514.
  • Kamat SS, Bagaria A, Kumaran D, Holmes-Hampton GP, Fan H, Sali A, et al. Catalytic mechanism and three-dimensional structure of adenine deaminase. Biochemistry. 2011;50(11):1917-27. doi: 10.1021/bi101788n. PubMed PMID: 21247091; PubMed Central PMCID: PMC3059353.
  • Kamat SS, Holmes-Hampton GP, Bagaria A, Kumaran D, Tichy SE, Gheyi T, et al. The catalase activity of diiron adenine deaminase. Protein science : a publication of the Protein Society. 2011;20(12):2080-94. doi: 10.1002/pro.748. PubMed PMID: 21998098; PubMed Central PMCID: PMC3302651.
  • Karakas E, Simorowski N, Furukawa H. Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature. 2011;475(7355):249-53. doi: 10.1038/nature10180. PubMed PMID: 21677647; PubMed Central PMCID: PMC3171209.
  • Ke W, Sampson JM, Ori C, Prati F, Drawz SM, Bethel CR, et al. Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors. Antimicrobial agents and chemotherapy. 2011;55(1):174-83. doi: 10.1128/AAC.00930-10. PubMed PMID: 21041505; PubMed Central PMCID: PMC3019678.
  • Koksal M, Jin Y, Coates RM, Croteau R, Christianson DW. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature. 2011;469(7328):116-20. doi: 10.1038/nature09628. PubMed PMID: 21160477; PubMed Central PMCID: PMC3059769.
  • Kucera K, Harrison LM, Cappello M, Modis Y. Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins. Journal of molecular biology. 2011;408(1):9-17. doi: 10.1016/j.jmb.2011.02.033. PubMed PMID: 21352830; PubMed Central PMCID: PMC3070796.
  • Kumar VS, O'Neall-Hennessey E, Reshetnikova L, Brown JH, Robinson H, Szent-Gyorgyi AG, et al. Crystal structure of a phosphorylated light chain domain of scallop smooth-muscle myosin. Biophysical journal. 2011;101(9):2185-9. doi: 10.1016/j.bpj.2011.09.028. PubMed PMID: 22067157; PubMed Central PMCID: PMC3207169.
  • Langelier MF, Planck JL, Roy S, Pascal JM. Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity. The Journal of biological chemistry. 2011;286(12):10690-701. doi: 10.1074/jbc.M110.202507. PubMed PMID: 21233213; PubMed Central PMCID: PMC3060520.
  • Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 2011;469(7331):564-7. doi: 10.1038/nature09638. PubMed PMID: 21240259; PubMed Central PMCID: PMC3064491.
  • Li Y, Wang Q, Mariuzza RA. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. The Journal of experimental medicine. 2011;208(4):703-14. doi: 10.1084/jem.20102548. PubMed PMID: 21422170; PubMed Central PMCID: PMC3135353.
  • Mancusso R, Karpowich NK, Czyzewski BK, Wang DN. Simple screening method for improving membrane protein thermostability. Methods. 2011;55(4):324-9. doi: 10.1016/j.ymeth.2011.07.008. PubMed PMID: 21840396; PubMed Central PMCID: PMC3220791.
  • Mecinovic J, Snyder PW, Mirica KA, Bai S, Mack ET, Kwant RL, et al. Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase. Journal of the American Chemical Society. 2011;133(35):14017-26. doi: 10.1021/ja2045293. PubMed PMID: 21790183; PubMed Central PMCID: PMC3171206.
  • Meinke G, Phelan P, Fradet-Turcotte A, Archambault J, Bullock PA. Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain. Acta crystallographica Section D, Biological crystallography. 2011;67(Pt 6):560-7. doi: 10.1107/S0907444911014302. PubMed PMID: 21636896; PubMed Central PMCID: PMC3107053.
  • Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA. Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA. Journal of virology. 2011;85(2):818-27. doi: 10.1128/JVI.01738-10. PubMed PMID: 20980496; PubMed Central PMCID: PMC3020010.
  • Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, et al. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nature structural & molecular biology. 2011;18(5):604-13. doi: 10.1038/nsmb.2021. PubMed PMID: 21478864; PubMed Central PMCID: PMC3087843.
  • Painter CA, Negroni MP, Kellersberger KA, Zavala-Ruiz Z, Evans JE, Stern LJ. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(48):19329-34. doi: 10.1073/pnas.1108074108. PubMed PMID: 22084083; PubMed Central PMCID: PMC3228433.
  • Parashar V, Mirouze N, Dubnau DA, Neiditch MB. Structural basis of response regulator dephosphorylation by Rap phosphatases. PLoS biology. 2011;9(2):e1000589. doi: 10.1371/journal.pbio.1000589. PubMed PMID: 21346797; PubMed Central PMCID: PMC3035606.
  • Park SY, Jin W, Woo JR, Shoelson SE. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. The Journal of biological chemistry. 2011;286(20):18130-8. doi: 10.1074/jbc.M110.217323. PubMed PMID: 21454505; PubMed Central PMCID: PMC3093885.
  • Phan G, Remaut H, Wang T, Allen WJ, Pirker KF, Lebedev A, et al. Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature. 2011;474(7349):49-53. doi: 10.1038/nature10109. PubMed PMID: 21637253; PubMed Central PMCID: PMC3162478.
  • Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, et al. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell. 2011;145(5):692-706. doi: 10.1016/j.cell.2011.03.053. PubMed PMID: 21596426; PubMed Central PMCID: PMC3135172.
  • Samanta D, Mukherjee G, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, et al. Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(33):13682-7. doi: 10.1073/pnas.1110971108. PubMed PMID: 21825122; PubMed Central PMCID: PMC3158197.
  • Sampson JM, Ke W, Bethel CR, Pagadala SR, Nottingham MD, Bonomo RA, et al. Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrobial agents and chemotherapy. 2011;55(5):2303-9. doi: 10.1128/AAC.01360-10. PubMed PMID: 21357298; PubMed Central PMCID: PMC3088229.
  • Sethi DK, Schubert DA, Anders AK, Heroux A, Bonsor DA, Thomas CP, et al. A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. The Journal of experimental medicine. 2011;208(1):91-102. doi: 10.1084/jem.20100725. PubMed PMID: 21199956; PubMed Central PMCID: PMC3023130.
  • Shenoy RT, Thangamani S, Velazquez-Campoy A, Ho B, Ding JL, Sivaraman J. Structural basis for dual-inhibition mechanism of a non-classical Kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin. PloS one. 2011;6(4):e18838. doi: 10.1371/journal.pone.0018838. PubMed PMID: 21541315; PubMed Central PMCID: PMC3082530.
  • Shi W, Chance MR. Metalloproteomics: forward and reverse approaches in metalloprotein structural and functional characterization. Current opinion in chemical biology. 2011;15(1):144-8. doi: 10.1016/j.cbpa.2010.11.004. PubMed PMID: 21130021; PubMed Central PMCID: PMC3040278.
  • Shi W, Punta M, Bohon J, Sauder JM, D'Mello R, Sullivan M, et al. Characterization of metalloproteins by high-throughput X-ray absorption spectroscopy. Genome research. 2011;21(6):898-907. doi: 10.1101/gr.115097.110. PubMed PMID: 21482623; PubMed Central PMCID: PMC3106322.
  • Smith KD, Shanahan CA, Moore EL, Simon AC, Strobel SA. Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(19):7757-62. doi: 10.1073/pnas.1018857108. PubMed PMID: 21518891; PubMed Central PMCID: PMC3093532.
  • Tian Y, Simanshu DK, Ma JB, Patel DJ. Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(3):903-10. doi: 10.1073/pnas.1017762108. PubMed PMID: 21193640; PubMed Central PMCID: PMC3024652.
  • Vance KM, Simorowski N, Traynelis SF, Furukawa H. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nature communications. 2011;2:294. doi: 10.1038/ncomms1295. PubMed PMID: 21522138; PubMed Central PMCID: PMC3302728.
  • Vasquez-Del Carpio R, Silverstein TD, Lone S, Johnson RE, Prakash L, Prakash S, et al. Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer. Journal of molecular biology. 2011;408(2):252-61. doi: 10.1016/j.jmb.2011.02.042. PubMed PMID: 21354175; PubMed Central PMCID: PMC3093752.
  • Wang XX, Li Y, Yin Y, Mo M, Wang Q, Gao W, et al. Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(38):15960-5. doi: 10.1073/pnas.1109438108. PubMed PMID: 21900604; PubMed Central PMCID: PMC3179091.
  • Weinberg DE, Nakanishi K, Patel DJ, Bartel DP. The inside-out mechanism of Dicers from budding yeasts. Cell. 2011;146(2):262-76. doi: 10.1016/j.cell.2011.06.021. PubMed PMID: 21784247; PubMed Central PMCID: PMC3169304.
  • Whitney JC, Hay ID, Li C, Eckford PD, Robinson H, Amaya MF, et al. Structural basis for alginate secretion across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(32):13083-8. doi: 10.1073/pnas.1104984108. PubMed PMID: 21778407; PubMed Central PMCID: PMC3156188.
  • Whorton MR, MacKinnon R. Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell. 2011;147(1):199-208. doi: 10.1016/j.cell.2011.07.046. PubMed PMID: 21962516; PubMed Central PMCID: PMC3243363.
  • Xia S, Wang M, Lee HR, Sinha A, Blaha G, Christian T, et al. Variation in mutation rates caused by RB69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. Journal of molecular biology. 2011;406(4):558-70. doi: 10.1016/j.jmb.2010.12.033. PubMed PMID: 21216248; PubMed Central PMCID: PMC3059800.
  • Xu B, Pizarro JC, Holmes MA, McBeth C, Groh V, Spies T, et al. Crystal structure of a gammadelta T-cell receptor specific for the human MHC class I homolog MICA. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(6):2414-9. doi: 10.1073/pnas.1015433108. PubMed PMID: 21262824; PubMed Central PMCID: PMC3038733.
  • Xue Y, Lee S, Wang Y, Ha Y. Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate. The Journal of biological chemistry. 2011;286(34):29748-57. doi: 10.1074/jbc.M111.219659. PubMed PMID: 21715329; PubMed Central PMCID: PMC3191016.
  • Yin Y, Li Y, Kerzic MC, Martin R, Mariuzza RA. Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. The EMBO journal. 2011;30(6):1137-48. doi: 10.1038/emboj.2011.21. PubMed PMID: 21297580; PubMed Central PMCID: PMC3061028.
  • Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP. Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. Journal of virology. 2011;85(1):632-7. doi: 10.1128/JVI.01683-10. PubMed PMID: 20962096; PubMed Central PMCID: PMC3014167.
  • Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, et al. Decoy strategies: the structure of TL1A:DcR3 complex. Structure. 2011;19(2):162-71. doi: 10.1016/j.str.2010.12.004. PubMed PMID: 21300286; PubMed Central PMCID: PMC3065972.
  • Zhang Y, Buchko GW, Qin L, Robinson H, Varnum SM. Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions. Biochemical and biophysical research communications. 2011;404(1):407-12. doi: 10.1016/j.bbrc.2010.11.134. PubMed PMID: 21130733; PubMed Central PMCID: PMC3019264.
2010
  • Aaron JA, Lin X, Cane DE, Christianson DW. Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. Biochemistry. 2010;49(8):1787-97. doi: 10.1021/bi902088z. PubMed PMID: 20131801; PubMed Central PMCID: PMC2840623.
  • Bae JH, Boggon TJ, Tome F, Mandiyan V, Lax I, Schlessinger J. Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(7):2866-71. doi: 10.1073/pnas.0914157107. PubMed PMID: 20133753; PubMed Central PMCID: PMC2840318.
  • Bandaranayake RM, Kolli M, King NM, Nalivaika EA, Heroux A, Kakizawa J, et al. The effect of clade-specific sequence polymorphisms on HIV-1 protease activity and inhibitor resistance pathways. Journal of virology. 2010;84(19):9995-10003. doi: 10.1128/JVI.00505-10. PubMed PMID: 20660190; PubMed Central PMCID: PMC2937823.
  • Beckman J, Wang M, Blaha G, Wang J, Konigsberg WH. Substitution of Ala for Tyr567 in RB69 DNA polymerase allows dAMP to be inserted opposite 7,8-dihydro-8-oxoguanine. Biochemistry. 2010;49(19):4116-25. doi: 10.1021/bi100102s. PubMed PMID: 20411947; PubMed Central PMCID: PMC2882254.
  • Bera AK, Atanasova V, Gamage S, Robinson H, Parsons JF. Structure of the D-alanylgriseoluteic acid biosynthetic protein EhpF, an atypical member of the ANL superfamily of adenylating enzymes. Acta crystallographica Section D, Biological crystallography. 2010;66(Pt 6):664-72. doi: 10.1107/S0907444910008425. PubMed PMID: 20516619; PubMed Central PMCID: PMC2879354.
  • Bick MJ, Banik JJ, Darst SA, Brady SF. Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry. 2010;49(19):4159-68. doi: 10.1021/bi100150v. PubMed PMID: 20361791; PubMed Central PMCID: PMC2888265.
  • Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, et al. Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase. Journal of the American Chemical Society. 2010;132(38):13320-31. doi: 10.1021/ja104092z. PubMed PMID: 20822105; PubMed Central PMCID: PMC3393087.
  • Brims DR, Qian J, Jarchum I, Mikesh L, Palmieri E, Ramagopal UA, et al. Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect. International immunology. 2010;22(3):191-203. doi: 10.1093/intimm/dxp127. PubMed PMID: 20093428; PubMed Central PMCID: PMC2829095.
  • Buchko GW, Robinson H, Abendroth J, Staker BL, Myler PJ. Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. Biochemical and biophysical research communications. 2010;394(4):1012-7. doi: 10.1016/j.bbrc.2010.03.112. PubMed PMID: 20331978; PubMed Central PMCID: PMC2856777.
  • Bulkley D, Innis CA, Blaha G, Steitz TA. Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(40):17158-63. doi: 10.1073/pnas.1008685107. PubMed PMID: 20876130; PubMed Central PMCID: PMC2951403.
  • Cappadocia L, Marechal A, Parent JS, Lepage E, Sygusch J, Brisson N. Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair. The Plant cell. 2010;22(6):1849-67. doi: 10.1105/tpc.109.071399. PubMed PMID: 20551348; PubMed Central PMCID: PMC2910959.
  • Chao JA, Patskovsky Y, Patel V, Levy M, Almo SC, Singer RH. ZBP1 recognition of beta-actin zipcode induces RNA looping. Genes & development. 2010;24(2):148-58. doi: 10.1101/gad.1862910. PubMed PMID: 20080952; PubMed Central PMCID: PMC2807350.
  • Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, et al. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(25):11313-8. doi: 10.1073/pnas.1002716107. PubMed PMID: 20534506; PubMed Central PMCID: PMC2895110.
  • Delfosse V, Bouchard P, Bonneau E, Dagenais P, Lemay JF, Lafontaine DA, et al. Riboswitch structure: an internal residue mimicking the purine ligand. Nucleic acids research. 2010;38(6):2057-68. doi: 10.1093/nar/gkp1080. PubMed PMID: 20022916; PubMed Central PMCID: PMC2847212.
  • Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, et al. A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(30):13408-13. doi: 10.1073/pnas.1005475107. PubMed PMID: 20616002; PubMed Central PMCID: PMC2922149.
  • Feng L, Campbell EB, Hsiung Y, MacKinnon R. Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science. 2010;330(6004):635-41. doi: 10.1126/science.1195230. PubMed PMID: 20929736; PubMed Central PMCID: PMC3079386.
  • Fogel AI, Li Y, Giza J, Wang Q, Lam TT, Modis Y, et al. N-glycosylation at the SynCAM (synaptic cell adhesion molecule) immunoglobulin interface modulates synaptic adhesion. The Journal of biological chemistry. 2010;285(45):34864-74. doi: 10.1074/jbc.M110.120865. PubMed PMID: 20739279; PubMed Central PMCID: PMC2966101.
  • Frey KM, Georgiev I, Donald BR, Anderson AC. Predicting resistance mutations using protein design algorithms. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(31):13707-12. doi: 10.1073/pnas.1002162107. PubMed PMID: 20643959; PubMed Central PMCID: PMC2922245.
  • Frey KM, Lombardo MN, Wright DL, Anderson AC. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. Journal of structural biology. 2010;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. PubMed PMID: 20026215; PubMed Central PMCID: PMC2841211.
  • Gu M, Rice CM. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(2):521-8. doi: 10.1073/pnas.0913380107. PubMed PMID: 20080715; PubMed Central PMCID: PMC2818896.
  • Hall RS, Agarwal R, Hitchcock D, Sauder JM, Burley SK, Swaminathan S, et al. Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase. Biochemistry. 2010;49(20):4374-82. doi: 10.1021/bi100252s. PubMed PMID: 20415463; PubMed Central PMCID: PMC2892419.
  • Han Q, Ding H, Robinson H, Christensen BM, Li J. Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase. PloS one. 2010;5(1):e8826. doi: 10.1371/journal.pone.0008826. PubMed PMID: 20098687; PubMed Central PMCID: PMC2809104.
  • Hauk G, McKnight JN, Nodelman IM, Bowman GD. The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor. Molecular cell. 2010;39(5):711-23. doi: 10.1016/j.molcel.2010.08.012. PubMed PMID: 20832723; PubMed Central PMCID: PMC2950701.
  • Ho MC, Shi W, Rinaldo-Matthis A, Tyler PC, Evans GB, Clinch K, et al. Four generations of transition-state analogues for human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(11):4805-12. doi: 10.1073/pnas.0913439107. PubMed PMID: 20212140; PubMed Central PMCID: PMC2841916.
  • Hoopes JT, Liu X, Xu X, Demeler B, Folta-Stogniew E, Li C, et al. Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. The Journal of biological chemistry. 2010;285(3):2165-73. doi: 10.1074/jbc.M109.018432. PubMed PMID: 19906646; PubMed Central PMCID: PMC2804372.
  • Huang CH, Gabelli SB, Oldfield E, Amzel LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 2010;78(4):888-99. doi: 10.1002/prot.22614. PubMed PMID: 19876942; PubMed Central PMCID: PMC3018326.
  • Huang CS, Sadre-Bazzaz K, Shen Y, Deng B, Zhou ZH, Tong L. Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase. Nature. 2010;466(7309):1001-5. doi: 10.1038/nature09302. PubMed PMID: 20725044; PubMed Central PMCID: PMC2925307.
  • Ipsaro JJ, Harper SL, Messick TE, Marmorstein R, Mondragon A, Speicher DW. Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. Blood. 2010;115(23):4843-52. doi: 10.1182/blood-2010-01-261396. PubMed PMID: 20197550; PubMed Central PMCID: PMC2890174.
  • Jackson RN, Klauer AA, Hintze BJ, Robinson H, van Hoof A, Johnson SJ. The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing. The EMBO journal. 2010;29(13):2205-16. doi: 10.1038/emboj.2010.107. PubMed PMID: 20512111; PubMed Central PMCID: PMC2905245.
  • Keiski CL, Harwich M, Jain S, Neculai AM, Yip P, Robinson H, et al. AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. Structure. 2010;18(2):265-73. doi: 10.1016/j.str.2009.11.015. PubMed PMID: 20159471; PubMed Central PMCID: PMC2857933.
  • Kim WM, Sigalov AB, Stern LJ. Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRzeta fragments. Acta crystallographica Section D, Biological crystallography. 2010;66(Pt 2):163-75. doi: 10.1107/S090744490904880X. PubMed PMID: 20124696; PubMed Central PMCID: PMC2815668.
  • Koksal M, Zimmer I, Schnitzler JP, Christianson DW. Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission. Journal of molecular biology. 2010;402(2):363-73. doi: 10.1016/j.jmb.2010.07.009. PubMed PMID: 20624401; PubMed Central PMCID: PMC2942996.
  • Kolyada A, Lee CJ, De Biasio A, Beglova N. A novel dimeric inhibitor targeting Beta2GPI in Beta2GPI/antibody complexes implicated in antiphospholipid syndrome. PloS one. 2010;5(12):e15345. doi: 10.1371/journal.pone.0015345. PubMed PMID: 21179511; PubMed Central PMCID: PMC3002267.
  • Krasteva PV, Fong JC, Shikuma NJ, Beyhan S, Navarro MV, Yildiz FH, et al. Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science. 2010;327(5967):866-8. doi: 10.1126/science.1181185. PubMed PMID: 20150502; PubMed Central PMCID: PMC2828054.
  • Kucera K, Koblansky AA, Saunders LP, Frederick KB, De La Cruz EM, Ghosh S, et al. Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. Journal of molecular biology. 2010;403(4):616-29. doi: 10.1016/j.jmb.2010.09.022. PubMed PMID: 20851125; PubMed Central PMCID: PMC2957522.
  • Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, et al. Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation. The Journal of biological chemistry. 2010;285(49):38524-33. doi: 10.1074/jbc.M110.172072. PubMed PMID: 20889499; PubMed Central PMCID: PMC2992285.
  • Li D, Li H, Wang T, Pan H, Lin G, Li H. Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome. The EMBO journal. 2010;29(12):2037-47. doi: 10.1038/emboj.2010.95. PubMed PMID: 20461058; PubMed Central PMCID: PMC2892373.
  • Li X, Zhang R, Zhang H, He Y, Ji W, Min W, et al. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. The Journal of biological chemistry. 2010;285(31):24099-107. doi: 10.1074/jbc.M110.128470. PubMed PMID: 20489202; PubMed Central PMCID: PMC2911348.
  • Li Y, Depontieu FR, Sidney J, Salay TM, Engelhard VH, Hunt DF, et al. Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells. Journal of molecular biology. 2010;399(4):596-603. doi: 10.1016/j.jmb.2010.04.037. PubMed PMID: 20417641; PubMed Central PMCID: PMC2904831.
  • Li Y, Hao B. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. The Journal of biological chemistry. 2010;285(18):13896-906. doi: 10.1074/jbc.M110.111518. PubMed PMID: 20181953; PubMed Central PMCID: PMC2859552.
  • Li Y, Setlow B, Setlow P, Hao B. Crystal structure of the GerBC component of a Bacillus subtilis spore germinant receptor. Journal of molecular biology. 2010;402(1):8-16. doi: 10.1016/j.jmb.2010.07.018. PubMed PMID: 20654628; PubMed Central PMCID: PMC3607951.
  • Lilic M, Quezada CM, Stebbins CE. A conserved domain in type III secretion links the cytoplasmic domain of InvA to elements of the basal body. Acta crystallographica Section D, Biological crystallography. 2010;66(Pt 6):709-13. doi: 10.1107/S0907444910010796. PubMed PMID: 20516623; PubMed Central PMCID: PMC2879356.
  • Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, et al. Mechanism of action and inhibition of dehydrosqualene synthase. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(50):21337-42. doi: 10.1073/pnas.1010907107. PubMed PMID: 21098670; PubMed Central PMCID: PMC3003041.
  • Lin G, Li D, Chidawanyika T, Nathan C, Li H. Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Archives of biochemistry and biophysics. 2010;501(2):214-20. doi: 10.1016/j.abb.2010.06.009. PubMed PMID: 20558127; PubMed Central PMCID: PMC2930046.
  • Lin L, Gardsvoll H, Huai Q, Huang M, Ploug M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. The Journal of biological chemistry. 2010;285(14):10982-92. doi: 10.1074/jbc.M109.093492. PubMed PMID: 20133942; PubMed Central PMCID: PMC2856303.
  • Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 2010;465(7300):885-90. doi: 10.1038/nature09121. PubMed PMID: 20485341; PubMed Central PMCID: PMC2888693.
  • Lin YW, Yeung N, Gao YG, Miner KD, Tian S, Robinson H, et al. Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(19):8581-6. doi: 10.1073/pnas.1000526107. PubMed PMID: 20421510; PubMed Central PMCID: PMC2889330.
  • Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, et al. Structural basis for methylarginine-dependent recognition of Aubergine by Tudor. Genes & development. 2010;24(17):1876-81. doi: 10.1101/gad.1956010. PubMed PMID: 20713507; PubMed Central PMCID: PMC2932969.
  • LowKam C, Liotard B, Sygusch J. Structure of a class I tagatose-1,6-bisphosphate aldolase: investigation into an apparent loss of stereospecificity. The Journal of biological chemistry. 2010;285(27):21143-52. doi: 10.1074/jbc.M109.080358. PubMed PMID: 20427286; PubMed Central PMCID: PMC2898290.
  • Ma X, Beuve A, van den Akker F. Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase. BMC structural biology. 2010;10:2. doi: 10.1186/1472-6807-10-2. PubMed PMID: 20105301; PubMed Central PMCID: PMC2828450.
  • Malashkevich VN, Dulyaninova NG, Ramagopal UA, Liriano MA, Varney KM, Knight D, et al. Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(19):8605-10. doi: 10.1073/pnas.0913660107. PubMed PMID: 20421509; PubMed Central PMCID: PMC2889333.
  • Mehere P, Han Q, Lemkul JA, Vavricka CJ, Robinson H, Bevan DR, et al. Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations. Protein & cell. 2010;1(11):1023-32. doi: 10.1007/s13238-010-0128-5. PubMed PMID: 21153519; PubMed Central PMCID: PMC3023147.
  • Mendes KR, Kantrowitz ER. A cooperative Escherichia coli aspartate transcarbamoylase without regulatory subunits. Biochemistry. 2010;49(35):7694-703. doi: 10.1021/bi1010333. PubMed PMID: 20681545; PubMed Central PMCID: PMC2935174.
  • Mendes KR, Kantrowitz ER. The pathway of product release from the R state of aspartate transcarbamoylase. Journal of molecular biology. 2010;401(5):940-8. doi: 10.1016/j.jmb.2010.07.003. PubMed PMID: 20620149; PubMed Central PMCID: PMC2955890.
  • Mitton-Fry RM, DeGregorio SJ, Wang J, Steitz TA, Steitz JA. Poly(A) tail recognition by a viral RNA element through assembly of a triple helix. Science. 2010;330(6008):1244-7. doi: 10.1126/science.1195858. PubMed PMID: 21109672; PubMed Central PMCID: PMC3074936.
  • Montange RK, Mondragon E, van Tyne D, Garst AD, Ceres P, Batey RT. Discrimination between closely related cellular metabolites by the SAM-I riboswitch. Journal of molecular biology. 2010;396(3):761-72. doi: 10.1016/j.jmb.2009.12.007. PubMed PMID: 20006621; PubMed Central PMCID: PMC2822714.
  • Murphy JW, Yuan H, Kong Y, Xiong Y, Lolis EJ. Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family. Proteins. 2010;78(5):1331-7. doi: 10.1002/prot.22666. PubMed PMID: 20077567; PubMed Central PMCID: PMC3021379.
  • Nair PA, Smith P, Shuman S. Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(29):12822-7. doi: 10.1073/pnas.1005830107. PubMed PMID: 20616014; PubMed Central PMCID: PMC2919965.
  • Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE. Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nature structural & molecular biology. 2010;17(1):130-2. doi: 10.1038/nsmb.1705. PubMed PMID: 19966800; PubMed Central PMCID: PMC3006182.
  • Nezami A, Poy F, Toms A, Zheng W, Eck MJ. Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins. PloS one. 2010;5(9). doi: 10.1371/journal.pone.0012992. PubMed PMID: 20927338; PubMed Central PMCID: PMC2948013.
  • Nguyen HH, Wang L, Huang H, Peisach E, Dunaway-Mariano D, Allen KN. Structural determinants of substrate recognition in the HAD superfamily member D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB). Biochemistry. 2010;49(6):1082-92. doi: 10.1021/bi902019q. PubMed PMID: 20050614; PubMed Central PMCID: PMC2844806.
  • Perederina A, Esakova O, Quan C, Khanova E, Krasilnikov AS. Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain. The EMBO journal. 2010;29(4):761-9. doi: 10.1038/emboj.2009.396. PubMed PMID: 20075859; PubMed Central PMCID: PMC2829168.
  • Phillips CM, Schreiter ER, Stultz CM, Drennan CL. Structural basis of low-affinity nickel binding to the nickel-responsive transcription factor NikR from Escherichia coli. Biochemistry. 2010;49(36):7830-8. doi: 10.1021/bi100923j. PubMed PMID: 20704276; PubMed Central PMCID: PMC2934763.
  • Piatkevich KD, Malashkevich VN, Almo SC, Verkhusha VV. Engineering ESPT pathways based on structural analysis of LSSmKate red fluorescent proteins with large Stokes shift. Journal of the American Chemical Society. 2010;132(31):10762-70. doi: 10.1021/ja101974k. PubMed PMID: 20681709; PubMed Central PMCID: PMC2919691.
  • Qi Y, Spong MC, Nam K, Karplus M, Verdine GL. Entrapment and structure of an extrahelical guanine attempting to enter the active site of a bacterial DNA glycosylase, MutM. The Journal of biological chemistry. 2010;285(2):1468-78. doi: 10.1074/jbc.M109.069799. PubMed PMID: 19889642; PubMed Central PMCID: PMC2801272.
  • Ravindranathan KP, Mandiyan V, Ekkati AR, Bae JH, Schlessinger J, Jorgensen WL. Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening. Journal of medicinal chemistry. 2010;53(4):1662-72. doi: 10.1021/jm901386e. PubMed PMID: 20121196; PubMed Central PMCID: PMC2842983.
  • Sadre-Bazzaz K, Whitby FG, Robinson H, Formosa T, Hill CP. Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening. Molecular cell. 2010;37(5):728-35. doi: 10.1016/j.molcel.2010.02.002. PubMed PMID: 20227375; PubMed Central PMCID: PMC2859072.
  • Schauder C, Ma LC, Krug RM, Montelione GT, Guan R. Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85beta subunit reveals conformational plasticity in the interhelical turn region. Acta crystallographica Section F, Structural biology and crystallization communications. 2010;66(Pt 12):1567-71. doi: 10.1107/S1744309110041333. PubMed PMID: 21139197; PubMed Central PMCID: PMC2998356.
  • Shaban NM, Harvey S, Perrino FW, Hollis T. The structure of the mammalian RNase H2 complex provides insight into RNA.NA hybrid processing to prevent immune dysfunction. The Journal of biological chemistry. 2010;285(6):3617-24. doi: 10.1074/jbc.M109.059048. PubMed PMID: 19923215; PubMed Central PMCID: PMC2823502.
  • Shi H, Blobel G. UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(50):21382-7. doi: 10.1073/pnas.1013038107. PubMed PMID: 21115842; PubMed Central PMCID: PMC3003015.
  • Silverstein TD, Jain R, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta. Structure. 2010;18(11):1463-70. doi: 10.1016/j.str.2010.08.019. PubMed PMID: 21070945; PubMed Central PMCID: PMC3044447.
  • Silverstein TD, Johnson RE, Jain R, Prakash L, Prakash S, Aggarwal AK. Structural basis for the suppression of skin cancers by DNA polymerase eta. Nature. 2010;465(7301):1039-43. doi: 10.1038/nature09104. PubMed PMID: 20577207; PubMed Central PMCID: PMC3030469.
  • Stadtmueller BM, Ferrell K, Whitby FG, Heroux A, Robinson H, Myszka DG, et al. Structural models for interactions between the 20S proteasome and its PAN/19S activators. The Journal of biological chemistry. 2010;285(1):13-7. doi: 10.1074/jbc.C109.070425. PubMed PMID: 19889631; PubMed Central PMCID: PMC2804157.
  • Stanley RE, Blaha G, Grodzicki RL, Strickler MD, Steitz TA. The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome. Nature structural & molecular biology. 2010;17(3):289-93. doi: 10.1038/nsmb.1755. PubMed PMID: 20154709; PubMed Central PMCID: PMC2917106.
  • Subach OM, Malashkevich VN, Zencheck WD, Morozova KS, Piatkevich KD, Almo SC, et al. Structural characterization of acylimine-containing blue and red chromophores in mTagBFP and TagRFP fluorescent proteins. Chemistry & biology. 2010;17(4):333-41. doi: 10.1016/j.chembiol.2010.03.005. PubMed PMID: 20416505; PubMed Central PMCID: PMC2862997.
  • Talreja S, Perry SL, Guha S, Bhamidi V, Zukoski CF, Kenis PJ. Determination of the phase diagram for soluble and membrane proteins. The journal of physical chemistry B. 2010;114(13):4432-41. doi: 10.1021/jp911780z. PubMed PMID: 20235520; PubMed Central PMCID: PMC2848416.
  • Tanaka N, Smith P, Shuman S. Structure of the RNA 3'-phosphate cyclase-adenylate intermediate illuminates nucleotide specificity and covalent nucleotidyl transfer. Structure. 2010;18(4):449-57. doi: 10.1016/j.str.2010.01.016. PubMed PMID: 20399182; PubMed Central PMCID: PMC2858066.
  • Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R. A gating charge transfer center in voltage sensors. Science. 2010;328(5974):67-73. doi: 10.1126/science.1185954. PubMed PMID: 20360102; PubMed Central PMCID: PMC2869078.
  • Teplova M, Song J, Gaw HY, Teplov A, Patel DJ. Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure. 2010;18(10):1364-77. doi: 10.1016/j.str.2010.06.018. PubMed PMID: 20947024; PubMed Central PMCID: PMC3381513.
  • Tremblay LW, Fan F, Blanchard JS. Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry. 2010;49(17):3766-73. doi: 10.1021/bi100232q. PubMed PMID: 20353175; PubMed Central PMCID: PMC2860635.
  • Tremblay LW, Xu H, Blanchard JS. Structures of the Michaelis complex (1.2 A) and the covalent acyl intermediate (2.0 A) of cefamandole bound in the active sites of the Mycobacterium tuberculosis beta-lactamase K73A and E166A mutants. Biochemistry. 2010;49(45):9685-7. doi: 10.1021/bi1015088. PubMed PMID: 20961112; PubMed Central PMCID: PMC2981129.
  • Tsai PC, Fan Y, Kim J, Yang L, Almo SC, Gao YQ, et al. Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase. Biochemistry. 2010;49(37):7988-97. doi: 10.1021/bi101058z. PubMed PMID: 20695627; PubMed Central PMCID: PMC2945819.
  • Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, et al. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010;468(7326):927-32. doi: 10.1038/nature09542. PubMed PMID: 21164480; PubMed Central PMCID: PMC3058826.
  • Waight AB, Love J, Wang DN. Structure and mechanism of a pentameric formate channel. Nature structural & molecular biology. 2010;17(1):31-7. doi: 10.1038/nsmb.1740. PubMed PMID: 20010838; PubMed Central PMCID: PMC3613427.
  • Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H. Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis. Journal of medicinal chemistry. 2010;53(4):1726-31. doi: 10.1021/jm901519f. PubMed PMID: 20121115; PubMed Central PMCID: PMC2831206.
  • Wang H, Robinson H, Ke H. Conformation changes, N-terminal involvement, and cGMP signal relay in the phosphodiesterase-5 GAF domain. The Journal of biological chemistry. 2010;285(49):38149-56. doi: 10.1074/jbc.M110.141614. PubMed PMID: 20861010; PubMed Central PMCID: PMC2992248.
  • Wang T, Darwin KH, Li H. Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nature structural & molecular biology. 2010;17(11):1352-7. doi: 10.1038/nsmb.1918. PubMed PMID: 20953180; PubMed Central PMCID: PMC2988878.
  • Weadge JT, Yip PP, Robinson H, Arnett K, Tipton PA, Howell PL. Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas aeruginosa AlgX. Acta crystallographica Section F, Structural biology and crystallization communications. 2010;66(Pt 5):588-91. doi: 10.1107/S1744309110011851. PubMed PMID: 20445266; PubMed Central PMCID: PMC2864699.
  • Wolfe LS, Calabrese MF, Nath A, Blaho DV, Miranker AD, Xiong Y. Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(39):16863-8. doi: 10.1073/pnas.1002867107. PubMed PMID: 20826442; PubMed Central PMCID: PMC2947910.
  • Xiang DF, Patskovsky Y, Xu C, Fedorov AA, Fedorov EV, Sisco AA, et al. Functional identification and structure determination of two novel prolidases from cog1228 in the amidohydrolase superfamily. Biochemistry. 2010;49(31):6791-803. doi: 10.1021/bi100897u. PubMed PMID: 20604542; PubMed Central PMCID: PMC2914802.
  • Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, et al. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 2010;467(7316):729-33. doi: 10.1038/nature09391. PubMed PMID: 20861839; PubMed Central PMCID: PMC3038789.
  • Yakubovskaya E, Mejia E, Byrnes J, Hambardjieva E, Garcia-Diaz M. Helix unwinding and base flipping enable human MTERF1 to terminate mitochondrial transcription. Cell. 2010;141(6):982-93. doi: 10.1016/j.cell.2010.05.018. PubMed PMID: 20550934; PubMed Central PMCID: PMC2887341.
  • Yang H, Wang J, Jia X, McNatt MW, Zang T, Pan B, et al. Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(43):18428-32. doi: 10.1073/pnas.1011485107. PubMed PMID: 20940320; PubMed Central PMCID: PMC2972963.
  • Yang Y, Xie P, Opatowsky Y, Schlessinger J. Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(5):1906-11. doi: 10.1073/pnas.0914052107. PubMed PMID: 20080685; PubMed Central PMCID: PMC2836632.
  • Yin de LT, Bernhardt P, Morley KL, Jiang Y, Cheeseman JD, Purpero V, et al. Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase. Biochemistry. 2010;49(9):1931-42. doi: 10.1021/bi9021268. PubMed PMID: 20112920; PubMed Central PMCID: PMC2855817.
  • Yu LP, Kim YS, Tong L. Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(51):22072-7. doi: 10.1073/pnas.1012039107. PubMed PMID: 21135213; PubMed Central PMCID: PMC3009786.
  • Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science. 2010;329(5988):182-6. doi: 10.1126/science.1190414. PubMed PMID: 20508092; PubMed Central PMCID: PMC3022345.
  • Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, et al. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry. 2010;49(43):9280-91. doi: 10.1021/bi101131f. PubMed PMID: 20839809; PubMed Central PMCID: PMC3001272.
  • Zhang Y, Buchko GW, Qin L, Robinson H, Varnum SM. Structural analysis of the receptor binding domain of botulinum neurotoxin serotype D. Biochemical and biophysical research communications. 2010;401(4):498-503. doi: 10.1016/j.bbrc.2010.09.063. PubMed PMID: 20858456; PubMed Central PMCID: PMC2975405.
  • Zhang Y, Gao X, Qin L, Buchko GW, Robinson H, Varnum SM. High-level expression, purification, crystallization and preliminary X-ray crystallographic studies of the receptor-binding domain of botulinum neurotoxin serotype D. Acta crystallographica Section F, Structural biology and crystallization communications. 2010;66(Pt 12):1610-3. doi: 10.1107/S1744309110039874. PubMed PMID: 21139207; PubMed Central PMCID: PMC2998366.
  • Zheng C, Kabaleeswaran V, Wang Y, Cheng G, Wu H. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. Molecular cell. 2010;38(1):101-13. doi: 10.1016/j.molcel.2010.03.009. PubMed PMID: 20385093; PubMed Central PMCID: PMC2855162.
2009
  • Back J, Malchiodi EL, Cho S, Scarpellino L, Schneider P, Kerzic MC, et al. Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis. Immunity. 2009;31(4):598-608. doi: 10.1016/j.immuni.2009.07.007. PubMed PMID: 19818651; PubMed Central PMCID: PMC2770797.
  • Bera AK, Atanasova V, Robinson H, Eisenstein E, Coleman JP, Pesci EC, et al. Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate. Biochemistry. 2009;48(36):8644-55. doi: 10.1021/bi9009055. PubMed PMID: 19694421; PubMed Central PMCID: PMC2775144.
  • Bernhards RC, Jing X, Vogelaar NJ, Robinson H, Schubot FD. Structural evidence suggests that antiactivator ExsD from Pseudomonas aeruginosa is a DNA binding protein. Protein science : a publication of the Protein Society. 2009;18(3):503-13. doi: 10.1002/pro.48. PubMed PMID: 19235906; PubMed Central PMCID: PMC2760357.
  • Bowley SR, Okumura N, Lord ST. Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions. Biochemistry. 2009;48(36):8656-63. doi: 10.1021/bi900239b. PubMed PMID: 19650644; PubMed Central PMCID: PMC2956063.
  • Brandao TA, Robinson H, Johnson SJ, Hengge AC. Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. Journal of the American Chemical Society. 2009;131(2):778-86. doi: 10.1021/ja807418b. PubMed PMID: 19140798; PubMed Central PMCID: PMC2739089.
  • Buchko GW. Pentapeptide Repeat Proteins and Cyanobacteria. Handbook on Cyanobacteria: Biochemistry, Biotechnology and Applications 2009.
  • Burgos ES, Ho MC, Almo SC, Schramm VL. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(33):13748-53. doi: 10.1073/pnas.0903898106. PubMed PMID: 19666527; PubMed Central PMCID: PMC2728965.
  • Castano T, Wang H, Campillo NE, Ballester S, Gonzalez-Garcia C, Hernandez J, et al. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. ChemMedChem. 2009;4(5):866-76. doi: 10.1002/cmdc.200900043. PubMed PMID: 19350606; PubMed Central PMCID: PMC2952885.
  • Chattopadhyay K, Ramagopal UA, Nathenson SG, Almo SC. 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. Acta crystallographica Section D, Biological crystallography. 2009;65(Pt 5):434-9. doi: 10.1107/S0907444909005721. PubMed PMID: 19390148; PubMed Central PMCID: PMC2672815.
  • Cheng A, Speir JA, Yuan YA, Johnson JE, Wong SM. Preliminary X-ray data analysis of crystalline hibiscus chlorotic ringspot virus. Acta crystallographica Section F, Structural biology and crystallization communications. 2009;65(Pt 6):589-93. doi: 10.1107/S1744309109015760. PubMed PMID: 19478438; PubMed Central PMCID: PMC2688417.
  • Chou CY, Yu LP, Tong L. Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. The Journal of biological chemistry. 2009;284(17):11690-7. doi: 10.1074/jbc.M805783200. PubMed PMID: 19213731; PubMed Central PMCID: PMC2670172.
  • Chung YS, Brendler T, Austin S, Guarne A. Structural insights into the cooperative binding of SeqA to a tandem GATC repeat. Nucleic acids research. 2009;37(10):3143-52. doi: 10.1093/nar/gkp151. PubMed PMID: 19304745; PubMed Central PMCID: PMC2691817.
  • Clayton GM, Aller SG, Wang J, Unger V, Morais-Cabral JH. Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channel. Journal of structural biology. 2009;167(3):220-6. doi: 10.1016/j.jsb.2009.06.012. PubMed PMID: 19545635; PubMed Central PMCID: PMC2922748.
  • Cochrane JC, Lipchock SV, Smith KD, Strobel SA. Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme. Biochemistry. 2009;48(15):3239-46. doi: 10.1021/bi802069p. PubMed PMID: 19228039; PubMed Central PMCID: PMC2854835.
  • Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274):739-44. doi: 10.1038/nature08617. PubMed PMID: 19935646; PubMed Central PMCID: PMC2818760.
  • Drumm JE, Mi K, Bilder P, Sun M, Lim J, Bielefeldt-Ohmann H, et al. Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection. PLoS pathogens. 2009;5(5):e1000460. doi: 10.1371/journal.ppat.1000460. PubMed PMID: 19478878; PubMed Central PMCID: PMC2682197.
  • Ezezika OC, Younger NS, Lu J, Kaiser DA, Corbin ZA, Nolen BJ, et al. Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin. The Journal of biological chemistry. 2009;284(4):2088-97. doi: 10.1074/jbc.M807073200. PubMed PMID: 19028693; PubMed Central PMCID: PMC2629104.
  • Fang Y, Jayaram H, Shane T, Kolmakova-Partensky L, Wu F, Williams C, et al. Structure of a prokaryotic virtual proton pump at 3.2 A resolution. Nature. 2009;460(7258):1040-3. doi: 10.1038/nature08201. PubMed PMID: 19578361; PubMed Central PMCID: PMC2745212.
  • Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance. Journal of molecular biology. 2009;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. PubMed PMID: 19249312; PubMed Central PMCID: PMC2723953.
  • Gallagher DT, Smith N, Kim SK, Robinson H, Reddy PT. Profound asymmetry in the structure of the cAMP-free cAMP Receptor Protein (CRP) from Mycobacterium tuberculosis. The Journal of biological chemistry. 2009;284(13):8228-32. doi: 10.1074/jbc.C800215200. PubMed PMID: 19193643; PubMed Central PMCID: PMC2659179.
  • Gallagher DT, Smith NN, Kim SK, Robinson H, Reddy PT. Protein Crystal Engineering of YpAC-IV using the Strategy of Excess Charge Reduction. Crystal growth & design. 2009;9(8):3570-4. doi: 10.1021/cg9003142. PubMed PMID: 20160955; PubMed Central PMCID: PMC2758785.
  • Garrett TP, Burgess AW, Gan HK, Luwor RB, Cartwright G, Walker F, et al. Antibodies specifically targeting a locally misfolded region of tumor associated EGFR. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(13):5082-7. doi: 10.1073/pnas.0811559106. PubMed PMID: 19289842; PubMed Central PMCID: PMC2656555.
  • Gelinas AD, Paschini M, Reyes FE, Heroux A, Batey RT, Lundblad V, et al. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(46):19298-303. doi: 10.1073/pnas.0909203106. PubMed PMID: 19884503; PubMed Central PMCID: PMC2780795.
  • Gurel G, Blaha G, Moore PB, Steitz TA. U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. Journal of molecular biology. 2009;389(1):146-56. doi: 10.1016/j.jmb.2009.04.005. PubMed PMID: 19362093; PubMed Central PMCID: PMC2682339.
  • Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL. Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nature chemical biology. 2009;5(4):251-7. doi: 10.1038/nchembio.153. PubMed PMID: 19270684; PubMed Central PMCID: PMC2743263.
  • Han Q, Robinson H, Cai T, Tagle DA, Li J. Biochemical and structural properties of mouse kynurenine aminotransferase III. Molecular and cellular biology. 2009;29(3):784-93. doi: 10.1128/MCB.01272-08. PubMed PMID: 19029248; PubMed Central PMCID: PMC2630683.
  • Han Q, Robinson H, Cai T, Tagle DA, Li J. Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K. Journal of medicinal chemistry. 2009;52(9):2786-93. doi: 10.1021/jm9000874. PubMed PMID: 19338303; PubMed Central PMCID: PMC2844090.
  • Hearn EM, Patel DR, Lepore BW, Indic M, van den Berg B. Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature. 2009;458(7236):367-70. doi: 10.1038/nature07678. PubMed PMID: 19182779; PubMed Central PMCID: PMC2658730.
  • Heroux A, Bozinovski DM, Valley MP, Fitzpatrick PF, Orville AM. Crystal structures of intermediates in the nitroalkane oxidase reaction. Biochemistry. 2009;48(15):3407-16. doi: 10.1021/bi8023042. PubMed PMID: 19265437; PubMed Central PMCID: PMC2754721.
  • Ho MC, Cassera MB, Madrid DC, Ting LM, Tyler PC, Kim K, et al. Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry. 2009;48(40):9618-26. doi: 10.1021/bi9012484. PubMed PMID: 19728741; PubMed Central PMCID: PMC2771402.
  • Ho MC, Sturm MB, Almo SC, Schramm VL. Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(48):20276-81. doi: 10.1073/pnas.0911606106. PubMed PMID: 19920175; PubMed Central PMCID: PMC2787146.
  • Ibrahim BS, Kanneganti N, Rieckhof GE, Das A, Laurents DV, Palenchar JB, et al. Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(32):13242-7. doi: 10.1073/pnas.0904309106. PubMed PMID: 19666603; PubMed Central PMCID: PMC2726365.
  • Karakas E, Simorowski N, Furukawa H. Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. The EMBO journal. 2009;28(24):3910-20. doi: 10.1038/emboj.2009.338. PubMed PMID: 19910922; PubMed Central PMCID: PMC2797058.
  • Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, et al. The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nature chemical biology. 2009;5(12):891-5. doi: 10.1038/nchembio.237. PubMed PMID: 19838203; PubMed Central PMCID: PMC2847429.
  • Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(41):17325-30. doi: 10.1073/pnas.0906600106. PubMed PMID: 19805034; PubMed Central PMCID: PMC2765077.
  • Levin EJ, Quick M, Zhou M. Crystal structure of a bacterial homologue of the kidney urea transporter. Nature. 2009;462(7274):757-61. doi: 10.1038/nature08558. PubMed PMID: 19865084; PubMed Central PMCID: PMC2871279.
  • Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, et al. Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction. PLoS pathogens. 2009;5(8):e1000537. doi: 10.1371/journal.ppat.1000537. PubMed PMID: 19662165; PubMed Central PMCID: PMC2714988.
  • Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, et al. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. The EMBO journal. 2009;28(3):286-97. doi: 10.1038/emboj.2008.288. PubMed PMID: 19153605; PubMed Central PMCID: PMC2637340.
  • Lim HH, Miller C. Intracellular proton-transfer mutants in a CLC Cl-/H+ exchanger. The Journal of general physiology. 2009;133(2):131-8. doi: 10.1085/jgp.200810112. PubMed PMID: 19139174; PubMed Central PMCID: PMC2638202.
  • Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors. Chemical biology & drug design. 2009;73(1):62-74. doi: 10.1111/j.1747-0285.2008.00745.x. PubMed PMID: 19152636; PubMed Central PMCID: PMC2838185.
  • Matthews LA, Duong A, Prasad AA, Duncker BP, Guarne A. Crystallization and preliminary X-ray diffraction analysis of motif N from Saccharomyces cerevisiae Dbf4. Acta crystallographica Section F, Structural biology and crystallization communications. 2009;65(Pt 9):890-4. doi: 10.1107/S1744309109029376. PubMed PMID: 19724125; PubMed Central PMCID: PMC2795593.
  • Mitchell M, Nam HJ, Carter A, McCall A, Rence C, Bennett A, et al. Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9. Acta crystallographica Section F, Structural biology and crystallization communications. 2009;65(Pt 7):715-8. doi: 10.1107/S1744309109021460. PubMed PMID: 19574648; PubMed Central PMCID: PMC2705643.
  • Nagy V, Hsia KC, Debler EW, Kampmann M, Davenport AM, Blobel G, et al. Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(42):17693-8. doi: 10.1073/pnas.0909373106. PubMed PMID: 19805193; PubMed Central PMCID: PMC2764879.
  • Navarro MV, De N, Bae N, Wang Q, Sondermann H. Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure. 2009;17(8):1104-16. doi: 10.1016/j.str.2009.06.010. PubMed PMID: 19679088; PubMed Central PMCID: PMC2747306.
  • Nayak V, Dessau M, Kucera K, Anthony K, Ledizet M, Modis Y. Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion. Journal of virology. 2009;83(9):4338-44. doi: 10.1128/JVI.02574-08. PubMed PMID: 19244332; PubMed Central PMCID: PMC2668458.
  • Nolen BJ, Tomasevic N, Russell A, Pierce DW, Jia Z, McCormick CD, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009;460(7258):1031-4. doi: 10.1038/nature08231. PubMed PMID: 19648907; PubMed Central PMCID: PMC2780427.
  • Orville AM, Lountos GT, Finnegan S, Gadda G, Prabhakar R. Crystallographic, spectroscopic, and computational analysis of a flavin C4a-oxygen adduct in choline oxidase. Biochemistry. 2009;48(4):720-8. doi: 10.1021/bi801918u. PubMed PMID: 19133805; PubMed Central PMCID: PMC2646362.
  • Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, et al. Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone. The Journal of biological chemistry. 2009;284(2):945-53. doi: 10.1074/jbc.M806833200. PubMed PMID: 18955486; PubMed Central PMCID: PMC2613614.
  • Perry SL, Roberts GW, Tice JD, Gennis RB, Kenis PJ. Microfluidic Generation of Lipidic Mesophases for Membrane Protein Crystallization. Crystal growth & design. 2009;9(6):2566-9. doi: 10.1021/cg900289d. PubMed PMID: 20161169; PubMed Central PMCID: PMC2721472.
  • Pieper U, Chiang R, Seffernick JJ, Brown SD, Glasner ME, Kelly L, et al. Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies. Journal of structural and functional genomics. 2009;10(2):107-25. doi: 10.1007/s10969-008-9056-5. PubMed PMID: 19219566; PubMed Central PMCID: PMC2693957.
  • Qi Y, Spong MC, Nam K, Banerjee A, Jiralerspong S, Karplus M, et al. Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature. 2009;462(7274):762-6. doi: 10.1038/nature08561. PubMed PMID: 20010681; PubMed Central PMCID: PMC2951314.
  • Ren Y, Yip CK, Tripathi A, Huie D, Jeffrey PD, Walz T, et al. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell. 2009;139(6):1119-29. doi: 10.1016/j.cell.2009.11.002. PubMed PMID: 20005805; PubMed Central PMCID: PMC2806190.
  • Richardson BC, Smith RD, Ungar D, Nakamura A, Jeffrey PD, Lupashin VV, et al. Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(32):13329-34. doi: 10.1073/pnas.0901966106. PubMed PMID: 19651599; PubMed Central PMCID: PMC2716380.
  • Schalch T, Job G, Noffsinger VJ, Shanker S, Kuscu C, Joshua-Tor L, et al. High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. Molecular cell. 2009;34(1):36-46. doi: 10.1016/j.molcel.2009.02.024. PubMed PMID: 19362535; PubMed Central PMCID: PMC2705653.
  • Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, et al. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature. 2009;457(7232):1019-22. doi: 10.1038/nature07606. PubMed PMID: 19118384; PubMed Central PMCID: PMC2661029.
  • Seo HS, Ma Y, Debler EW, Wacker D, Kutik S, Blobel G, et al. Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(34):14281-6. doi: 10.1073/pnas.0907453106. PubMed PMID: 19706512; PubMed Central PMCID: PMC2732846.
  • Sippel KH, Boehlein SK, Sakai Y, Quirit JG, Agbandje-McKenna M, Rosser CJ, et al. Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289. Acta crystallographica Section F, Structural biology and crystallization communications. 2009;65(Pt 9):910-2. doi: 10.1107/S1744309109030565. PubMed PMID: 19724130; PubMed Central PMCID: PMC2795598.
  • Smith KD, Lipchock SV, Ames TD, Wang J, Breaker RR, Strobel SA. Structural basis of ligand binding by a c-di-GMP riboswitch. Nature structural & molecular biology. 2009;16(12):1218-23. doi: 10.1038/nsmb.1702. PubMed PMID: 19898477; PubMed Central PMCID: PMC2850612.
  • Subach FV, Malashkevich VN, Zencheck WD, Xiao H, Filonov GS, Almo SC, et al. Photoactivation mechanism of PAmCherry based on crystal structures of the protein in the dark and fluorescent states. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(50):21097-102. doi: 10.1073/pnas.0909204106. PubMed PMID: 19934036; PubMed Central PMCID: PMC2795494.
  • Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structure of the human Rev1-DNA-dNTP ternary complex. Journal of molecular biology. 2009;390(4):699-709. doi: 10.1016/j.jmb.2009.05.026. PubMed PMID: 19464298; PubMed Central PMCID: PMC2739620.
  • Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta. Nature structural & molecular biology. 2009;16(9):979-86. doi: 10.1038/nsmb.1663. PubMed PMID: 19718023; PubMed Central PMCID: PMC3055789.
  • Tao X, Avalos JL, Chen J, MacKinnon R. Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science. 2009;326(5960):1668-74. doi: 10.1126/science.1180310. PubMed PMID: 20019282; PubMed Central PMCID: PMC2819303.
  • Tripathi A, Ren Y, Jeffrey PD, Hughson FM. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nature structural & molecular biology. 2009;16(2):114-23. doi: 10.1038/nsmb.1548. PubMed PMID: 19151722; PubMed Central PMCID: PMC2635920.
  • Tulsidas SR, Thangamani S, Ho B, Sivaraman J, Ding JL. Crystallization of a nonclassical Kazal-type Carcinoscorpius rotundicauda serine protease inhibitor, CrSPI-1, complexed with subtilisin. Acta crystallographica Section F, Structural biology and crystallization communications. 2009;65(Pt 5):533-5. doi: 10.1107/S1744309109014420. PubMed PMID: 19407396; PubMed Central PMCID: PMC2675604.
  • Wang T, Li H, Lin G, Tang C, Li D, Nathan C, et al. Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure. 2009;17(10):1377-85. doi: 10.1016/j.str.2009.08.010. PubMed PMID: 19836337; PubMed Central PMCID: PMC2775066.
  • Wang Y, Juranek S, Li H, Sheng G, Wardle GS, Tuschl T, et al. Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature. 2009;461(7265):754-61. doi: 10.1038/nature08434. PubMed PMID: 19812667; PubMed Central PMCID: PMC2880917.
  • Xiang DF, Patskovsky Y, Xu C, Meyer AJ, Sauder JM, Burley SK, et al. Functional identification of incorrectly annotated prolidases from the amidohydrolase superfamily of enzymes. Biochemistry. 2009;48(17):3730-42. doi: 10.1021/bi900111q. PubMed PMID: 19281183; PubMed Central PMCID: PMC2683473.
  • Xiang DF, Xu C, Kumaran D, Brown AC, Sauder JM, Burley SK, et al. Functional annotation of two new carboxypeptidases from the amidohydrolase superfamily of enzymes. Biochemistry. 2009;48(21):4567-76. doi: 10.1021/bi900453u. PubMed PMID: 19358546; PubMed Central PMCID: PMC2748308.
  • Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature. 2009;458(7239):784-8. doi: 10.1038/nature07731. PubMed PMID: 19194460; PubMed Central PMCID: PMC2739979.
  • Yin Q, Lamothe B, Darnay BG, Wu H. Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry. 2009;48(44):10558-67. doi: 10.1021/bi901462e. PubMed PMID: 19810754; PubMed Central PMCID: PMC2830148.
  • Zhan C, Yan Q, Patskovsky Y, Li Z, Toro R, Meyer A, et al. Biochemical and structural characterization of the human TL1A ectodomain. Biochemistry. 2009;48(32):7636-45. doi: 10.1021/bi900031w. PubMed PMID: 19522538; PubMed Central PMCID: PMC2790920.
  • Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, et al. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. Journal of the American Chemical Society. 2009;131(14):5153-62. doi: 10.1021/ja808285e. PubMed PMID: 19309137; PubMed Central PMCID: PMC2753403.
  • Zhao H, Heroux A, Sequeira RD, Tang L. Preliminary crystallographic studies of the regulatory domain of response regulator YycF from an essential two-component signal transduction system. Acta crystallographica Section F, Structural biology and crystallization communications. 2009;65(Pt 7):719-22. doi: 10.1107/S1744309109022696. PubMed PMID: 19574649; PubMed Central PMCID: PMC2705644.
  • Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature structural & molecular biology. 2009;16(6):652-7. doi: 10.1038/nsmb.1602. PubMed PMID: 19430461; PubMed Central PMCID: PMC2758934.
2008
  • Altieri SL, Clayton GM, Silverman WR, Olivares AO, De la Cruz EM, Thomas LR, et al. Structural and energetic analysis of activation by a cyclic nucleotide binding domain. Journal of molecular biology. 2008;381(3):655-69. doi: 10.1016/j.jmb.2008.06.011. PubMed PMID: 18619611; PubMed Central PMCID: PMC2555981.
  • Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, et al. Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase. Journal of medicinal chemistry. 2008;51(23):7532-40. doi: 10.1021/jm800776a. PubMed PMID: 19007108; PubMed Central PMCID: PMC2645930.
  • Cappadocia L, Sygusch J, Brisson N. Purification, crystallization and preliminary X-ray diffraction analysis of the Whirly domain of StWhy2 in complex with single-stranded DNA. Acta crystallographica Section F, Structural biology and crystallization communications. 2008;64(Pt 11):1056-9. doi: 10.1107/S1744309108032399. PubMed PMID: 18997341; PubMed Central PMCID: PMC2581700.
  • Chen W, Lam SS, Srinath H, Jiang Z, Correia JJ, Schiffer CA, et al. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nature structural & molecular biology. 2008;15(11):1213-20. doi: 10.1038/nsmb.1496. PubMed PMID: 18836453; PubMed Central PMCID: PMC2757928.
  • Collard F, Zhang J, Nemet I, Qanungo KR, Monnier VM, Yee VC. Crystal structure of the deglycating enzyme fructosamine oxidase (amadoriase II). The Journal of biological chemistry. 2008;283(40):27007-16. doi: 10.1074/jbc.M804885200. PubMed PMID: 18667417; PubMed Central PMCID: PMC2556003.
  • Demirci H, Gregory ST, Dahlberg AE, Jogl G. Multiple-site trimethylation of ribosomal protein L11 by the PrmA methyltransferase. Structure. 2008;16(7):1059-66. doi: 10.1016/j.str.2008.03.016. PubMed PMID: 18611379; PubMed Central PMCID: PMC2684062.
  • Dowling DP, Gantt SL, Gattis SG, Fierke CA, Christianson DW. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry. 2008;47(51):13554-63. doi: 10.1021/bi801610c. PubMed PMID: 19053282; PubMed Central PMCID: PMC2635894.
  • Han Q, Cai T, Tagle DA, Robinson H, Li J. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. Bioscience reports. 2008;28(4):205-15. doi: 10.1042/BSR20080085. PubMed PMID: 18620547; PubMed Central PMCID: PMC2559858.
  • Hsu Y, Jubelin G, Taieb F, Nougayrede JP, Oswald E, Stebbins CE. Structure of the cyclomodulin Cif from pathogenic Escherichia coli. Journal of molecular biology. 2008;384(2):465-77. doi: 10.1016/j.jmb.2008.09.051. PubMed PMID: 18845161; PubMed Central PMCID: PMC2659761.
  • Hu X, Wang H, Ke H, Kuhlman B. Computer-based redesign of a beta sandwich protein suggests that extensive negative design is not required for de novo beta sheet design. Structure. 2008;16(12):1799-805. doi: 10.1016/j.str.2008.09.013. PubMed PMID: 19081056; PubMed Central PMCID: PMC2688708.
  • Jayaram H, Accardi A, Wu F, Williams C, Miller C. Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(32):11194-9. doi: 10.1073/pnas.0804503105. PubMed PMID: 18678918; PubMed Central PMCID: PMC2516207.
  • Jones LL, Colf LA, Bankovich AJ, Stone JD, Gao YG, Chan CM, et al. Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Biochemistry. 2008;47(47):12398-408. doi: 10.1021/bi801349g. PubMed PMID: 18973345; PubMed Central PMCID: PMC2680728.
  • Kumaran D, Rawat R, Ahmed SA, Swaminathan S. Substrate binding mode and its implication on drug design for botulinum neurotoxin A. PLoS pathogens. 2008;4(9):e1000165. doi: 10.1371/journal.ppat.1000165. PubMed PMID: 18818739; PubMed Central PMCID: PMC2533696.
  • Lazar-Molnar E, Yan Q, Cao E, Ramagopal U, Nathenson SG, Almo SC. Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(30):10483-8. doi: 10.1073/pnas.0804453105. PubMed PMID: 18641123; PubMed Central PMCID: PMC2492495.
  • Lietha D, Eck MJ. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PloS one. 2008;3(11):e3800. doi: 10.1371/journal.pone.0003800. PubMed PMID: 19030106; PubMed Central PMCID: PMC2582962.
  • Martucci WE, Vargo MA, Anderson KS. Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase. Biochemistry. 2008;47(34):8902-11. doi: 10.1021/bi800466z. PubMed PMID: 18672899; PubMed Central PMCID: PMC2613286.
  • Meinke G, Ezeokonkwo C, Balbo P, Stafford W, Moore C, Bohm A. Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically disordered protein. Biochemistry. 2008;47(26):6859-69. doi: 10.1021/bi800204k. PubMed PMID: 18537269; PubMed Central PMCID: PMC2615413.
  • Moldoveanu T, Gehring K, Green DR. Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains. Nature. 2008;456(7220):404-8. doi: 10.1038/nature07353. PubMed PMID: 19020622; PubMed Central PMCID: PMC2847431.
  • Nolen BJ, Pollard TD. Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit. The Journal of biological chemistry. 2008;283(39):26490-8. doi: 10.1074/jbc.M802607200. PubMed PMID: 18640983; PubMed Central PMCID: PMC2546537.
  • Pan Y, Weng J, Kabaleeswaran V, Li H, Cao Y, Bhosle RC, et al. Cortisone dissociates the Shaker family K+ channels from their beta subunits. Nature chemical biology. 2008;4(11):708-14. doi: 10.1038/nchembio.114. PubMed PMID: 18806782; PubMed Central PMCID: PMC2633621.
  • Ragumani S, Kumaran D, Burley SK, Swaminathan S. Crystal structure of a putative lysostaphin peptidase from Vibrio cholerae. Proteins. 2008;72(3):1096-103. doi: 10.1002/prot.22095. PubMed PMID: 18498110; PubMed Central PMCID: PMC3614409.
  • Samanta U, Bahnson BJ. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. The Journal of biological chemistry. 2008;283(46):31617-24. doi: 10.1074/jbc.M804750200. PubMed PMID: 18784071; PubMed Central PMCID: PMC2581546.
  • Schubert HL, Phillips JD, Heroux A, Hill CP. Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex. Biochemistry. 2008;47(33):8648-55. doi: 10.1021/bi800635y. PubMed PMID: 18651750; PubMed Central PMCID: PMC2852885.
  • Singh SK, Piscitelli CL, Yamashita A, Gouaux E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science. 2008;322(5908):1655-61. doi: 10.1126/science.1166777. PubMed PMID: 19074341; PubMed Central PMCID: PMC2832577.
  • Song JJ, Kingston RE. WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. The Journal of biological chemistry. 2008;283(50):35258-64. doi: 10.1074/jbc.M806900200. PubMed PMID: 18840606; PubMed Central PMCID: PMC2596411.
  • Stanley BJ, Ehrlich ES, Short L, Yu Y, Xiao Z, Yu XF, et al. Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly. Journal of virology. 2008;82(17):8656-63. doi: 10.1128/JVI.00767-08. PubMed PMID: 18562529; PubMed Central PMCID: PMC2519636.
  • Tan YW, Yu HB, Leung KY, Sivaraman J, Mok YK. Structure of AscE and induced burial regions in AscE and AscG upon formation of the chaperone needle-subunit complex of type III secretion system in Aeromonas hydrophila. Protein science : a publication of the Protein Society. 2008;17(10):1748-60. doi: 10.1110/ps.036798.108. PubMed PMID: 18662905; PubMed Central PMCID: PMC2548367.
  • Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry. 2008;47(48):12760-8. doi: 10.1021/bi801487x. PubMed PMID: 18983167; PubMed Central PMCID: PMC2646200.
  • Wing RA, Bailey S, Steitz TA. Insights into the replisome from the structure of a ternary complex of the DNA polymerase III alpha-subunit. Journal of molecular biology. 2008;382(4):859-69. doi: 10.1016/j.jmb.2008.07.058. PubMed PMID: 18691598; PubMed Central PMCID: PMC2614274.
  • Xu Y, Chen Y, Zhang P, Jeffrey PD, Shi Y. Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Molecular cell. 2008;31(6):873-85. doi: 10.1016/j.molcel.2008.08.006. PubMed PMID: 18922469; PubMed Central PMCID: PMC2818795.
  • Zhang W, Cho Y, Lolis E, Howe JR. Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008;28(4):932-43. doi: 10.1523/JNEUROSCI.3309-07.2008. PubMed PMID: 18216201.
  • Zhou X, Sun Q, Kini RM, Sivaraman J. A universal method for fishing target proteins from mixtures of biomolecules using isothermal titration calorimetry. Protein science : a publication of the Protein Society. 2008;17(10):1798-804. doi: 10.1110/ps.036194.108. PubMed PMID: 18621915; PubMed Central PMCID: PMC2548376.
  • Zhou X, Tan TC, Valiyaveettil S, Go ML, Kini RM, Velazquez-Campoy A, et al. Structural characterization of myotoxic ecarpholin S from Echis carinatus venom. Biophysical journal. 2008;95(7):3366-80. doi: 10.1529/biophysj.107.117747. PubMed PMID: 18586854; PubMed Central PMCID: PMC2547436.
Theses
  • Butler E. Cooperative Ligand Binding in RNA: an Illustrated Guide to the Glycine Riboswitch [Ph.D.]2011.
  • Li H. Structural and Biochemical Studies of TIGAR and ZnuA [Ph.D.]2009.
  • Messing S. Structure and Function of the RNA Pyrophosphohydrolase BdRppH and the 9-cis-epoxy Carotenoid Dioxygenase VP14 [Ph.D.]2008.

X3A - Crystallography (Core C)

2013
  • Bjelic S, Wieser M, Frey D, Stirnimann CU, Chance MR, Jaussi R, et al. Structural basis for the oligomerization-state switch from a dimer to a trimer of an engineered cortexillin-1 coiled-coil variant. PloS one. 2013;8(5):e63370. doi: 10.1371/journal.pone.0063370. PubMed PMID: 23691037; PubMed Central PMCID: PMC3653964.
  • Mbonye UR, Gokulrangan G, Datt M, Dobrowolski C, Cooper M, Chance MR, et al. Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes. PLoS pathogens. 2013;9(5):e1003338. doi: 10.1371/journal.ppat.1003338. PubMed PMID: 23658523; PubMed Central PMCID: PMC3642088.
2012
  • Osmundson J, Montero-Diez C, Westblade LF, Hochschild A, Darst SA. Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell. 2012;151(5):1005-16. doi: 10.1016/j.cell.2012.10.034. PubMed PMID: 23178120; PubMed Central PMCID: PMC3604623.
2011
  • Twist KA, Campbell EA, Deighan P, Nechaev S, Jain V, Geiduschek EP, et al. Crystal structure of the bacteriophage T4 late-transcription coactivator gp33 with the beta-subunit flap domain of Escherichia coli RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(50):19961-6. doi: 10.1073/pnas.1113328108. PubMed PMID: 22135460; PubMed Central PMCID: PMC3250119.
2010
  • Cafasso J, Manjasetty BA, Karr EA, Sandman K, Chance MR, Reeve JN. Preliminary crystallography confirms that the archaeal DNA-binding and tryptophan-sensing regulator TrpY is a dimer. Acta crystallographica Section F, Structural biology and crystallization communications. 2010;66(Pt 11):1493-5. doi: 10.1107/S1744309110036031. PubMed PMID: 21045304; PubMed Central PMCID: PMC3001657.
  • Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, et al. Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. PLoS biology. 2010;8(9). doi: 10.1371/journal.pbio.1000483. PubMed PMID: 20856905; PubMed Central PMCID: PMC2939025.
  • Sampathkumar P, Lu F, Zhao X, Li Z, Gilmore J, Bain K, et al. Structure of a putative BenF-like porin from Pseudomonas fluorescens Pf-5 at 2.6 A resolution. Proteins. 2010;78(14):3056-62. doi: 10.1002/prot.22829. PubMed PMID: 20737437; PubMed Central PMCID: PMC2989796.
2009
  • Li H, Motamedi MR, Yip CK, Wang Z, Walz T, Patel DJ, et al. An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Molecular cell. 2009;34(2):155-67. doi: 10.1016/j.molcel.2009.02.032. PubMed PMID: 19394293; PubMed Central PMCID: PMC2756231.
  • Quezada CM, Hicks SW, Galan JE, Stebbins CE. A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases. Proceedings of the National Academy of Sciences of the United States of America. 2009;106(12):4864-9. doi: 10.1073/pnas.0811058106. PubMed PMID: 19273841; PubMed Central PMCID: PMC2653562.
2008
  • Kim J, Tsai PC, Chen SL, Himo F, Almo SC, Raushel FM. Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase. Biochemistry. 2008;47(36):9497-504. doi: 10.1021/bi800971v. PubMed PMID: 18702530; PubMed Central PMCID: PMC2725523.
  • Lamour V, Rutherford ST, Kuznedelov K, Ramagopal UA, Gourse RL, Severinov K, et al. Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein. Journal of molecular biology. 2008;383(2):367-79. doi: 10.1016/j.jmb.2008.08.011. PubMed PMID: 18760284; PubMed Central PMCID: PMC2613045.
  • Mancias JD, Goldberg J. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. The EMBO journal. 2008;27(21):2918-28. doi: 10.1038/emboj.2008.208. PubMed PMID: 18843296; PubMed Central PMCID: PMC2580787.
  • Stavropoulos P, Nagy V, Blobel G, Hoelz A. Molecular basis for the autoregulation of the protein acetyl transferase Rtt109. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(34):12236-41. doi: 10.1073/pnas.0805813105. PubMed PMID: 18719104; PubMed Central PMCID: PMC2527895.

U2B - Infrared Spectroscopy

2011
  • Korach C, Halada, G., Mubarez, H. Effects of Processing Conditions on Chitosan-Hydroxyapatite Biocomposite Mechanical Properties. In: Proulx T, editor. Mechanics of biological systems and materials Vol 2 : proceedings of the 2001 Annual Conference on Experimental and Applied Mechanics New York: Springer; 2011. p. 125-30.
  • Liu N, Yu PQ. Molecular clustering, interrelationships and carbohydrate conformation in hull and seeds among barley cultivars. J Cereal Sci. 2011;53(3):379-83. doi: DOI 10.1016/j.jcs.2011.02.011. PubMed PMID: WOS:000292226600016.
  • Wetzel D, Nasse, M. Synchrotron Infrared Confocal Microspectroscopic Spatial Resolution or a Customized Synchrotron/focal Plane Array System Enhances Chemical Imaging of Biological Tissue or Cells. Nuclear Instruments and Methods in Physics Research. 2011;649(1):179-83.
  • Yu P. SR-IMS Molecular Spectroscopic Image of Functional Groups in Biopolymers in Feed Systems. In: Elnashar M, editor. Biotechnology of Biopolymers 2011.
2010
  • Flynn GJ, Wirick S, Keller LP, Jacobsen C. Modification of the Murchison Insoluble Organic Matter (IOM) by Acid Extraction. Astrobiology Science Conference 2010: Evolution and Life: Surviving Catastrophes and Extremes on Earth and Beyond, held April 26-20, 2010 in League City, Texas LPI Contribution No 1538. 2010:5162.
  • Lehmann J, Solomon, D. . Organic Carbon Chemistry in Soils Observed by Synchrotron-Based Spectroscopy. In: Singh B, Grfe M, editors. Synchrotron-based techniques in soils and sediments. Amsterdam ; London: Elsevier; 2010. p. 289-312.
  • Mak KF, Sfeir MY, Misewich JA, Heinz TF. The evolution of electronic structure in few-layer graphene revealed by optical spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(34):14999-5004. doi: 10.1073/pnas.1004595107. PubMed PMID: 20696939; PubMed Central PMCID: PMC2930520.
  • Murdock JN, Dodds WK, Reffner JA, Wetzel DL. Measuring Cellular-Scale Nutrient Distribution in Algal Biofilms with Synchrotron Confocal Infrared Microspectroscopy. Spectroscopy. 2010;25(10):32-41. PubMed PMID: WOS:000283672500003.
  • Yu PQ, Damiran D, Liu D. Synchrotron Infrared Spectroscopy with Multivariate Spectral Analyses Potentially Facilitates the Classification of Inherent Structures of Feed-Type of Sorghum. Aip Conf Proc. 2010;1214:60-2. PubMed PMID: WOS:000287165600017.
2009
  • Smedley J, Jaye C, Bohon J, Rao T, Fischer DA. Laser patterning of diamond. Part II. Surface nondiamond carbon formation and its removal. J Appl Phys. 2009;105(12). doi: Artn 123108 Doi 10.1063/1.3152995. PubMed PMID: WOS:000267599600024.
2008
  • Bonwell ES, Fisher TL, Fritz AK, Wetzel DL. Determination of endosperm protein secondary structure in hard wheat breeding lines using synchrotron infrared microspectroscopy.
  • Vib Spectrosc
  • . 2008;48(1):76-81. doi: DOI 10.1016/j.vibspec.2008.04.002. PubMed PMID: WOS:000259283100014.
  • Miller SS, Fulcher, R.G. . Microstructure and Chemistry of the Oat Kernel. Oats: Chemistry and Technology (reference textbook)2008-2009.
  • Yu P. Synchrotron-Based Microspectroscopic Analysis of Molecular and Biopolymer Structures Using Multivariate Techniques and Advanced Multi-Components Modeling. Canadian Journal of Analytical Sciences and Spectroscopy. 2008;53.
Theses
  • Doiron K. Characterization Of Autoclaved Flaxseed As Feed For Ruminants Using Conventional And Mid-IR Spectroscopic Based Approaches [Ph.D.]2009.
  • Liu N. Ruminal Nutrient Availability and Inherent Structural Features of Six Barley Varieties Using in Situ Technique and Mid-IR Spectroscopy [M.S.]2009.